中国中药杂志

2019, v.44(18) 4048-4052

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基于网络药理学研究淫羊藿治疗骨质疏松症的分子作用机制
Molecular mechanism of Epimedii Folium in treatment of osteoporosis based on network pharmacology

柯志鹏;张新庄;曹泽彧;曹亮;王振中;肖伟;
KE Zhi-peng;ZHANG Xin-zhuang;CAO Ze-yu;CAO Liang;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

骨质疏松症是一种以骨量减少、骨组织微结构破坏、骨骼脆性增加和易发生骨折为特征的全身性疾病。随着人口老龄化的日趋严重,骨质疏松症已成为一个全球性的问题。目前,临床上所使用的化学合成药物均存在一定的副作用,利用传统中药及其制剂治疗该病已成为新的研究热点。淫羊藿是传统中药中用于治疗骨质疏松症最常用的药材之一,其药理活性引起了全球范围的广泛关注。该研究采用网络药理学的方法,探讨淫羊藿治疗骨质疏松症的主要活性成分和潜在的分子作用机制。化合物-靶点网络特征分析显示,分子网络度较高的多为黄酮类化合物,它们具有雌激素样作用、抗氧化和清除自由基等药理作用,能够起到预防和治疗骨质疏松症的作用;另一方面靶点网络度较高的多与性激素水平、破骨细胞分化、骨基质降解和体内活性氧水平等有关,淫羊藿中多个化合物可以与这些靶点相互作用。该研究表明淫羊藿可通过多个活性成分作用于多个靶点,来防治骨质疏松症。
Osteoporosis is a systematic bone disease,characterized by deterioration in bone mass or micro-architecture,and increasing risk of fragility and fractures. With the development of aging problems,osteoporosis has been a global health problem. At present,due to the undesirable side effects of synthetic osteoporosis inhibitors,more efforts are made in treatment of osteoporosis by traditional Chinese medicine and its prescriptions. Epimedii Folium,one of the most common herbs for osteoporosis,has attracted great attentions worldwide.In this study,network pharmacology was employed to analyze the active components and potential molecular mechanism of Epimedii Folium on osteoporosis. Component-target network analysis showed that those with higher molecular network degree were flavonoids,with estrogen-like activity,antioxidation and free radical-scavenging activities,playing certain roles in preventing and treating osteoporosis. On the other hand,the targets with high degree were mostly related with sex hormone,osteoclast differentiation,bone matrix degradation,and reactive oxygen species in drug-target network. Multiple components of Epimedii Folium could be interacted with these targets. This study shows that Epimedium could prevent and treat osteoporosis through multiple active ingredients acting on multiple targets.

关键词(KeyWords): 骨质疏松症;淫羊藿;网络药理学;分子对接
osteoporosis;Epimedii Folium;network pharmacology;molecular docking

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作者(Author): 柯志鹏;张新庄;曹泽彧;曹亮;王振中;肖伟;
KE Zhi-peng;ZHANG Xin-zhuang;CAO Ze-yu;CAO Liang;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

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