中国中药杂志

2007, (01) 39-41

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知母中的生物碱
Studies on the alkaloids of Anemarrhena asphodeloides

沈莉;戴胜军;赵大洲;
SHEN Li~(1,2),DAI Sheng-jun~(2),ZHAO Da-zhou~(3)(1.Ocean University of China,Qingdao 266003,China;2.School of Pharmacy,Yantai University,Yantai 264005,China;3.Shandong Luye Pharmaceutical Co.,Ltd,Yantai 264003,China)

摘要(Abstract):

目的:研究知母中的生物碱成分。方法:Sephadex LH-20,Rp-18及硅胶色谱柱分离纯化,根据理化性质和光谱数据鉴定结构。结果:分离鉴定了6个生物碱,分别为aurantiam ide acetate(1)、环(酪-亮)二肽(2)、香豆酰基酪胺(3)、N-反式阿魏酰基酪胺(4)、N-顺式阿魏酰基酪胺(5)、烟酸(6)。结论:化合物1~5为首次从百合科植物中分离得到,化合物1~6为首次从知母中分离得到。
Objective: To investigate the alkaloids of Anemarrhena asphodeloides.Method: The compounds were isolated and purified by Sephadex LH-20,Rp-18 and silica gel column chromatography.Their chemical structures were elucidated on the basis of physicochemical properties and spectral data(IR,FAB-MS,~(1)H-NMR,and ~(13)C-NMR).Result: Six compounds were isolated and identified as: aurantiamide acetate(1),cyclo(Tyr-Leu)(2),N-p-coumaroyltyramine(3), N-trans-feruloyltyramine(4),N-cis-feruloyltyramine(5),and nicotinic acid(6),respectively.Conclusion: For the first time,compounds 1-5 were separated from Liliacae plant,and compounds 1-6 were obtained from this plant.

关键词(KeyWords): 知母;化学成分;生物碱
Anemarrhena asphodeloides;chemical constituents;alkaloid

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作者(Author): 沈莉;戴胜军;赵大洲;
SHEN Li~(1,2),DAI Sheng-jun~(2),ZHAO Da-zhou~(3)(1.Ocean University of China,Qingdao 266003,China;2.School of Pharmacy,Yantai University,Yantai 264005,China;3.Shandong Luye Pharmaceutical Co.,Ltd,Yantai 264003,China)

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