中国中药杂志

1999, (08) 3-5

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丹皮酚抗鹌鹑实验性动脉粥样硬化作用
Inhibitory Effect of Paeonol on Experimental Atherosclerosis in Quails

戴敏,訾晓梅,彭代银,刘青云
Dai Min,Zhi Xiaomei,Peng Daiyin and Liu Qingyun (Anhui College of Traditional Chinese Medicine,Hefei 230038)

摘要(Abstract):

目的:研究丹皮酚对鹌鹑实验性动脉粥样硬化的抑制作用。方法:观察丹皮酚灌胃给药(600,300mg·kg-1)后在鹌鹑实验性动脉粥样硬化形成中调节血脂、改善血液流变学、减轻主动脉脂质斑块形成的作用。结果:口饲丹皮酚可明显降低实验动物血清TC,TG,LDL,vLDL,apoB100含量,提高HDL含量及HDL/TC,HDL2/HDL3,apoA1/apoB100比值;不同程度地降低低切变率下全血比粘度、血浆比粘度、纤维蛋白原比粘度、红细胞聚集性。显著减少主动脉壁及肝脏TC含量,缩小斑块面积,抑制主动脉脂质斑块形成。结论:口饲丹皮酚具有抗鹌鹑实验性动脉粥样硬化作用
Objective:To study the effect of paeonol on experimental atherosclerosis in quails caused by high lipid feeding.Method:The effects of oral administration of 300 and 600mg/kg of paeonol on lipid levels in serum,hemorrheology and aortic intimal abnormalities were investigated.Result:Paeonol decreased TC,TG,LDL,vLDL,APOB 100 levels in serum and TC levels in aorta and liver.The ratios of HDL/TC,HDL 2/HDL 3, apoA 1/apoB 100 were elevated.In addition,the drug reduced the whole blood viscosity,Plasma viscosity and plasma fibrinogen,and inhibited erythrocyte aggregation.Conclusion:Oral administration of paeonol can reduce the development of atherosclerosis.

关键词(KeyWords): 丹皮酚,动脉粥样硬化,脂质,血液流变学
paeonol;atherosclerosis;lipid;hemorrheology (original article on page 488)

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作者(Author): 戴敏,訾晓梅,彭代银,刘青云
Dai Min,Zhi Xiaomei,Peng Daiyin and Liu Qingyun (Anhui College of Traditional Chinese Medicine,Hefei 230038)

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