中国中药杂志

2019, v.44(02) 212-217

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基于活血化瘀功效的温苦肝、寒苦肝性效关系研究
Nature-effect relationship research of cold and warm medicinal properties of traditional Chinese medicine for promoting blood circulation and removing blood stasis based on nature combination

李晶;吴东雪;候宁;刘敏;张燕玲;乔延江;
LI Jing;WU Dong-xue;HOU Ning;LIU Min;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

摘要(Abstract):

活血化瘀中药是临床上常用的一类功能相同的药物,且多性属寒温,是研究中药药性和功效关系的优良载体。所以为了探讨活血化瘀中药的寒温差异与其功效的内在联系,该文通过数据库检索获取温苦肝、寒苦肝组合的主要有效成分及作用靶点,应用Cytoscape 3. 5. 1平台构建蛋白互作网络,采用Bin GO插件对识别出的功能模块进行功能注释和统计分析,结果表明苦-肝组合主要通过参与细胞周期、脂质代谢、血液循环等生命过程而发挥活血祛瘀的功效;寒性蛋白网络主要通过EDNRA等靶点参与血管收缩、通过PLAU等靶点调节凝血,从而发挥凉血消痈的功效;温性蛋白网络主要通过P2RY12等靶点参与调节血小板活化,从而发挥活血行气、通经止痛的功效。该研究从分子网络水平阐释了苦-肝组合的共性特征和温、寒的特异性特征,为中药的药性与功效的内在联系研究提供了新思路。
Traditional Chinese medicine for promoting blood circulation and removing blood stasis is a kind of drug with cold or warm medicinal properties which is commonly used in clinical practice. It is an excellent carrier for studying the nature-effect relationship of traditional Chinese medicine. Therefore,this study will acquire the main active components and targets based on the drug-based research method. The Cytoscape 3. 5. 1 platform was used to construct the protein interaction network,and the Bin GO plug-in was used to perform functional annotation and statistical analysis on the identified functional modules. The results showed that the bitter-liver protein interaction network mainly participates in cell cycle process,lipid catabolic process,blood circulation to exert the effect of promoting blood circulation and removing blood stasis; the cold protein interaction network mainly participates in vasoconstriction through targets such as EDNRA,regulates blood coagulation through targets such as PLAU,and thus exerts the effect of cooling blood and eliminating phlegm; warm protein interaction network mainly participates in the regulation of platelet activation through targets such as P2 RY12,thereby exerting the effect of promoting blood circulation,relieving pain and relieving pain. This study explains the common characteristics of the bitter-liver combination and the specific characteristics of cold or warm medicinal properties from the molecular network level,which provides a new idea for the intrinsic relationship between the medicinal properties and efficacy of traditional Chinese medicine.

关键词(KeyWords): 药性组合;蛋白互作网络;功能模块;活血化瘀
nature combination;protein interaction network;functional module;promoting blood circulation and removing blood stasis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(81430094);; 北京中医药大学自主课题项目(2018-JYBZZ-XS066)

作者(Author): 李晶;吴东雪;候宁;刘敏;张燕玲;乔延江;
LI Jing;WU Dong-xue;HOU Ning;LIU Min;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

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