中国中药杂志

2010, v.35(10) 1346-1348

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基于药物代谢组学的方剂配伍规律及配伍科学价值揭示
Elucidation of compatibility principle and scientiffic value of Chinese medical formulae based on pharmacometabolomics

王喜军;张伯礼;
WANG Xijun1,ZHANG Boli 2 (1.Heilongjiang University of Chinese Medicine,Harbin,150040,China;2.Tianjin University of Chinses Medicine,Tianjin,300193,China)

摘要(Abstract):

利用现代多维联用色谱技术,研究不同配伍情况下茵陈蒿汤口服后体内成分及其动态变化规律,阐明茵陈蒿汤有效成分的体内命运,阐释了该方药物代谢层面的配伍意义;同时利用代谢组学对整体代谢轮廓的描述,评价复杂性多元(方剂成分及代谢产物)输入的调整带来整体效应的变化,最大限度从对证侯的整体效应变化层面揭示配伍意义。在此基础上,提出了中医方剂药物代谢组学(pharmacometabolomics of chinmediformulae)的概念。
By using UPLC coupled with MS,the analysis of the constituents absorbed into blood after oral administration of Yinchenhao decotion with different conbination had been carried out,the body fate of constituents detected in the blood was elucidated also;At the same time,the overall body respones after multi-input of the medical formule were evaluated by metabolomic analysis.These data explained the scienfiffic values in both drug metabolisim and metabonomics,the results had given some new evidences for the potentialities of pharmacometabonomics to elucidate the compatibility principle of Chinese medical formule.As a conclusion,concept of "Pharmacometabolomics of Chinmediformulae"has been defined.

关键词(KeyWords): 茵陈蒿汤;代谢;血清药物化学;代谢组学;中医方剂药物代谢组学
Yinchenhao tang;serum pharmacochemistry;metabolism;metabolomics;pharmacometabolomics of chinmediformulae

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基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2005CB523406)

作者(Author): 王喜军;张伯礼;
WANG Xijun1,ZHANG Boli 2 (1.Heilongjiang University of Chinese Medicine,Harbin,150040,China;2.Tianjin University of Chinses Medicine,Tianjin,300193,China)

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