中国中药杂志

2019, v.44(02) 229-234

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

基于药性组合的姜黄、郁金、莪术的性效关系研究
Nature-effect relationship research of Curcumae Longae Rhizoma,Curcumae Radix,and Curcumae Rhizoma based on nature combination

吴东雪;候宁;李晶;刘敏;张燕玲;乔延江;
WU Dong-xue;HOU Ning;LI Jing;LIU Min;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

摘要(Abstract):

姜黄、郁金、莪术均来源于姜科植物,为同一植物的不同药用部分,但三者药性不同,从而产生的功效、针对的症状亦不相同,姜黄、莪术的药性组合均为温辛肝、温苦肝,郁金的药性组合为寒心肝、寒苦肝、寒辛心、寒苦心,对比分析郁金与姜黄、莪术的性效关系的相关性和差异性,阐释三者作用机制的异同点。该文以姜黄、郁金、莪术为研究载体,通过TCMD,TCMSP,Ch EMBL数据库获取其有效成分及作用靶点,构建蛋白互作网络,对网络进行模块聚类分析。姜黄、郁金的对比研究表明,姜黄性温,通过P2RY12,GNG2等基因调节血液凝固发挥通经止痛功效;郁金性寒,通过LDLR,APOB,PRKCA,SOD1,TP53等基因调节脂质代谢、血浆脂蛋白水平、血小板活化、氧化应激反应、凋亡等过程发挥清心凉血的功效。姜黄、郁金的对比研究表明,莪术性温,通过GRIA2,GRIA4等基因调节神经系统过程发挥其破血逐瘀的功效;郁金性寒,通过CALM1,LPL,APOB,SOD1,TP53等基因调节血小板活化、脂质代谢、血浆脂蛋白、氧化应激、凋亡过程发挥清心凉血的功效。姜黄、郁金、莪术三者均为辛苦味,归肝经,其活血功效可能与参与脂质代谢、血液凝固、血红蛋白、血小板脱粒等过程有关。通过对3味中药的网络进行聚类分析,有利于阐释药性组合与功效的内在联系,为药性与功效规律的研究奠定基础。
Curcumae Longae Rhizoma,Curcumae Radix and Curcumae Rhizoma are different medicinal parts of the same plant.Nevertheless,they are different in medicinal effects due to the different Chinese herbal nature. In this study,traditional Chinese medicines database( TCMD2009),traditional Chinese medicine system( TCMSP),and Ch EMBL database were retrieved to screen the active components and targets,and construct the target PPI network. By a graph theoretic clustering algorithm identifying protein complex algorithm( IPCA),the protein modules were identified and analyzed by gene ontology( GO) enrichment. A comparative study of Curcumae Longae Rhizoma and Curcumae Radix illustrate that Curcumae Longae Rhizoma regulates blood coagulation through P2 RY12,GNG2 and other genes to exert the analgesic effect. Curcumae Radix regulates lipid metabolism,plasma lipoprotein particle levels,platelet activation,response to oxidative stress,apoptotic process through LDLR,APOB,PRKCA,SOD1,TP53 and other genes to perform a function in clearing the heart and cooling the blood. A comparative study of Curcumae Radix and Curcumae Rhizoma demonstrate that Curcumae Rhizoma on regulates the nervous system by GRIA2,GRIA4 and other genes to exert blood-breaking effect; Curcumae Radix regulates lipid metabolism,plasma lipoprotein particle levels,platelet activation,response to oxidative stress,apoptotic process by genes such as CALM1,LPL,APOB,SOD1 and TP53 to play the role of clearing heart and cooling blood. Cluster analysis of the protein interaction network of the nature combination is helpful to explain the intrinsic link between the nature combination and efficacy.

关键词(KeyWords): 姜黄;郁金;莪术;蛋白互作网络;药性组合;性效关系
Curcumae Longae Rhizoma;Curcumae Radix;Curcumae Rhizoma;PPI network;nature combination;nature-effect relationship

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(81430094);; 北京中医药大学自主课题项目(2018-JYBZZ-XS066)

作者(Author): 吴东雪;候宁;李晶;刘敏;张燕玲;乔延江;
WU Dong-xue;HOU Ning;LI Jing;LIU Min;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享