中国中药杂志

2021, v.46(19) 5015-5019

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生姜中1个新的单萜酯成分
A new monoterpene ester from Zingiberis Rhizoma Recens

张晓娟;宋志敏;王彦志;王芸菲;蔡雅君;胡雪雨;冯卫生;
ZHANG Xiao-juan;SONG Zhi-min;WANG Yan-zhi;WANG Yun-fei;CAI Ya-jun;HU Xue-yu;FENG Wei-sheng;School of Pharmacy, Henan University of Chinese Medicine;Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province;

摘要(Abstract):

运用MCI、Sephadex LH-20、硅胶、半制备高效液相等多种色谱技术并结合TLC法,从生姜水部位的丙酮溶解物中分离得到5个化合物。并结合多种波谱学方法(1D-NMR、2D-NMR、MS等),对分离得到的单体化合物进行结构鉴定,分别鉴定为(2E, 6Z)-8-羟基-2, 6-二甲基辛基-2, 6-二烯-1-基-(E)-3-(4-羟基-3-甲氧基苯基)丙烯酸酯(1)、(2E, 6E)-8-羟基-3, 7-二甲基辛基-2, 6-二烯酸(2)、(E)-1, 8-二羟基-3, 7-二甲基-2-辛烯酸(3)、linalyl-β-D-glucopyranoside(4)、β-D-glucopyranoside-(2E)-3,7-dimethyl-2,6-octadien-1-yl(5)。其中,化合物1为新化合物,化合物4、5为首次从该植物中分离得到。
Five monoterpenoid compounds(1-5) were isolated and purified from the acetone fraction of the aqueous extract of Zingiberis Rhizoma Recens by MCI, Sephadex LH-20, silica gel, semi-preparative HPLC, and TLC. Their structures were identified with multiple spectroscopical methods including 1 D-NMR, 2 D-NMR, and MS. The five compounds were identified as(2E,6Z)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl-(E)-3-(4-hydroxy-3-methoxyphenyl) acrylate(1),(2E,6E)-8-hydroxy-3,7-dimethylocta-2,6-die-noic acid(2),(E)-1,8-dihydroxy-3,7-dimethyl-2-octenoic acid(3), linalyl-β-D-glucopyranoside(4), and β-D-glucopyranoside-(2E)-3,7-dimethyl-2,6-octadien-1-yl(5), respectively.Compound 1 was a new monoterpene ester, and compounds 4-5 were isolated from this plant for the first time.

关键词(KeyWords): 生姜;单萜酯;糖苷;分离鉴定
Zingiberis Rhizoma Recens;monoterpene ester;glycoside;isolation and identification

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基金项目(Foundation): 河南省自然科学基金面上项目(212300410368);; 河南省中医学科研究专项课题(20-21ZY1040)

作者(Author): 张晓娟;宋志敏;王彦志;王芸菲;蔡雅君;胡雪雨;冯卫生;
ZHANG Xiao-juan;SONG Zhi-min;WANG Yan-zhi;WANG Yun-fei;CAI Ya-jun;HU Xue-yu;FENG Wei-sheng;School of Pharmacy, Henan University of Chinese Medicine;Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province;

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