中国中药杂志

2021, v.46(19) 5152-5158

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基于中西医临床病症特点的类风湿性关节炎动物模型分析
Animal model analysis of rheumatoid arthritis based on clinical characteristics of Chinese and Western medicine

黄淑敏;钟森杰;廖晓倩;胡思远;胡志希;
HUANG Shu-min;ZHONG Sen-jie;LIAO Xiao-qian;HU Si-yuan;HU Zhi-xi;Hunan University of Chinese Medicine;

摘要(Abstract):

类风湿关节炎(rheumatoid arthritis, RA)是一种以对称的多发性关节炎为主要症状的自身免疫性疾病,该病的高致残率严重影响患者生活质量甚至威胁患者生命,建立良好的类风湿性关节炎动物模型对于RA的诊断及临床防治有着重要意义。基于RA中西医临床病症特点,对目前常见的类风湿性关节炎动物模型进行归纳总结,主要分为药物诱导性、基因相关性及病证结合三大类。在模型评价中,以关节肿胀、疼痛、发红、出现结节以及关节畸形等为主要标准,与临床上RA的诊断标准存在一定的差异。从辨证分型来看,病症结合模型只是单纯模拟了中医证型,与"RA"的形成无直接因果关系,尚需完善。该文在分析类风湿性关节炎动物模型的优缺点及其与中西医临床特征的吻合度同时提出相应的类风湿性关节炎动物模型评价和改进方向。为进一步完善中西医临床病症特点的类风湿性关节炎动物模型体系的建立提供建议,使类风湿性关节炎动物模型更贴近于临床,对类风湿性关节炎的临床诊断与治疗起到重要作用。
Rheumatoid arthritis(RA) is an autoimmune disease involving multiple joints bilaterally with symmetrical polyarthritis as the main symptom. The high disability rate of this disease seriously affects the quality of life of patients and even threatens their lives. The establishment of a good animal model is of great significance for the diagnosis and clinical prevention of RA. Based on the clinical characteristics of RA in traditional Chinese and Western medicine, the common animal models of RA were summarized, including drug-induced, gene-related, and syndrome and disease combined models. Joint swelling, pain, redness, nodules, and joint deformity are the main criteria for model evaluation, which have certain differences from the clinical diagnostic criteria of RA. From the perspective of syndrome differentiation, the animal model combining syndrome and disease only simulates the syndrome of traditional Chinese medicine and has no direct causal relationship with the formation of RA. In this paper, we analyzed the advantages and disadvantages of animal models of RA and the coincidence degree of the models with the clinical characteristics and then put forward the corresponding recommendations for the evaluation and improvement of these models, aiming to make the animal models of RA closer to the clinical symptoms and play an important role in the clinical diagnosis and treatment of RA.

关键词(KeyWords): 类风湿性关节炎;动物模型;临床病症特点
rheumatoid arthritis;animal models;clinical symptoms

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基金项目(Foundation): 国家自然科学基金项目(81774208);; 广东省重点领域研发项目(2020B1111100001);; 湖南省自然科学基金项目(2020JJ4062,2020JJ5408,2019JJ50447);; 湖南省研究生科研创新项目(CX20200784)

作者(Author): 黄淑敏;钟森杰;廖晓倩;胡思远;胡志希;
HUANG Shu-min;ZHONG Sen-jie;LIAO Xiao-qian;HU Si-yuan;HU Zhi-xi;Hunan University of Chinese Medicine;

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