中国中药杂志

2014, v.39(13) 2422-2427

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TRPV1离子通道与中药辛味药性的关系研究
Study on relations between transient receptor potential vanilloid 1 and pungent property of traditional Chinese medicines

王星;张燕玲;王耘;任真真;鲍红娟;乔延江;
WANG Xing;ZHANG Yan-ling;WANG Yun;REN Zhen-zhen;BAO Hong-juan;QIAO Yan-jiang;Information Engineering Research Center for Traditional Chinese Medicine,Beijing University of Chinese Medicine;Key Laboratory of Traditional Chinese Medicine Finish Processing and Health Product Development of Fujian Province,Xiamen Medical College;

摘要(Abstract):

中药五味理论及味效发生机制一直是中药药性研究领域的重点和难点。该文利用基于药效团的虚拟筛选技术,通过研究中药成分对TRPV1离子通道的调节作用探讨TRPV1与中药辛味药性之间的关系。结果发现TRPV1激动剂药效团模型与中药化学成分之间的匹配关系揭示了辛味中药的药效成分。因此,提出TRPV1离子通道是辛味药性发挥药效的潜在靶点之一。中药辛味药性是由其化学成分决定的,且在不同层次上符合继承性和加和性等特点。
The five-flavor theory of traditional Chinese medicines(TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper,by using the pharmacophore-based virtual screening technique,the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1(TRPV1) by studying the TCM components' role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs.Therefore,the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components,and consistent with the inherited and additive characteristics.

关键词(KeyWords): TRPV1离子通道;辛味药性;药效团;虚拟筛选
TRPV1 ion channel;pungent property;pharmacophore;virtual screening

Abstract:

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基金项目(Foundation): 国家科技支撑计划项目(2008BAI51B01);; 国家自然科学基金项目(81173522);; 北京中医药大学自主选题项目(2013-JYBZZ-XS-118)

作者(Author): 王星;张燕玲;王耘;任真真;鲍红娟;乔延江;
WANG Xing;ZHANG Yan-ling;WANG Yun;REN Zhen-zhen;BAO Hong-juan;QIAO Yan-jiang;Information Engineering Research Center for Traditional Chinese Medicine,Beijing University of Chinese Medicine;Key Laboratory of Traditional Chinese Medicine Finish Processing and Health Product Development of Fujian Province,Xiamen Medical College;

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