中国中药杂志

2016, v.41(03) 528-531

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《中医方剂大辞典》含丹参、红花药对组方规律数据挖掘分析
Data mining analysis of regularity of formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos medicin pair in Dictionary of Chinese Medicine Prescription

崔一然;刘欣;申丹;杨洪军;唐仕欢;
CUI Yi-ran;LIU Xin;SHEN Dan;YANG Hong-jun;TANG Shi-huan;Institute of Chinese Medica,China Academy of Chinese Medical Sciences;Department of Cardiology,Xiyuan Hospital,China Academy of Chinese Medical Sciences;

摘要(Abstract):

该研究基于《中医方剂大辞典》数据库,应用"中医传承辅助平台"系统,提取含丹参、红花药对的方剂,运用软件的关联规则,改进的互信息法等数据挖掘方法,分析丹参、红花药对用药规律。最终纳入方剂39首,涉及中药280味,使用频率除丹参、红花外最高的前5位中药依次为当归、川芎、香附、白芍、桃仁/生地黄。经过聚类得到核心药物6组,分别为丹参-香附-红花,丹参-白芍-红花,丹参-当归-香附-红花,丹参-当归-白芍-红花,红花-丹参-白芍-当归,丹参-白芍-红花-当归。设支持度11(38.46%),置信度80%,共得到关联规则38组。提示丹参、红花常与活血、行气之品联用,主以妇科病、瘀血疼痛证、中风等为治疗病证。
In this study,formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos in the database of Dictionary of Chinese Medicine Prescription( DCMP) were extracted by using traditional Chinese medicine inheritance support system( TCMISS).The drugs pairs and formula composition rules were analyzed with data mining methods,such as association rules,improved mutual information method and complex system entropy clustering. Totally 39 formulas were included in this study and involved 280 Chinese medicines. The top 5 Chinese medicines most frequently used were Danggui( Angelica sinensis),Chuanxiong( Ligusticum chuanxiong),Xiangfu( Cyperi Rhizoma),Baishao( Radix Paeoniae Alba),Taoren( Prunus persica) and Shengdihuang( Radix Rehmanniae Recens). Six core medicinal pairs were obtained through clustering analysis,namely Danshen( Salviae Miltiorrhizae Radix et Rhizoma)-Xiangfu( Cyperi Rhizoma)-Honghua( Carthami Flos),Danshen( Salviae Miltiorrhizae Radix et Rhizoma)-Baishao( Radix Paeoniae Alba)-Honghua( Carthami Flos),Danshen( Salviae Miltiorrhizae Radix et Rhizoma)-Danggui( A. sinensis)-Xiagnfu( Cyperi Rhizoma)-Honghua( Carthami Flos),Danshen( Salviae Miltiorrhizae Radix et Rhizoma)-Danggui( A. sinensis)-Baishao( Radix Paeoniae Alba)-Honghua( Carthami Flos),Honghua( Carthami Flos)-Danshen( Salviae Miltiorrhizae Radix et Rhizoma)-Baishao( Radix Paeoniae Alba)-Danggui( A. sinensis),Danshen( Salviae Miltiorrhizae Radix et Rhizoma)-Baishao( Radix Paeoniae Alba)-Honghua( Carthami Flos)-Danggui( A. sinensis). The support degree was set at 11( 38. 46%),with a confidence coefficient of 80%,and then 38 associated pairs were screened. These results suggested that Salviae Miltiorrhizae Radix et Rhizoma,Carthami Flos is often combined with herbs for activating blood and promoting circulation of qi to treat gynecopathy,stasis blood pain syndrome,stroke and other syndromes.

关键词(KeyWords): 丹参;红花;药对;数据挖掘;组方规律;中医方剂大辞典;中医传承辅助平台
Salviae Miltiorrhizae Radix et Rhizoma;Carthami Flos;medicine pair;data mining;medication regularity;Dictionary of Chinese Medicine Prescription;traditional Chinese medicine inheritance support system

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81330086)

作者(Author): 崔一然;刘欣;申丹;杨洪军;唐仕欢;
CUI Yi-ran;LIU Xin;SHEN Dan;YANG Hong-jun;TANG Shi-huan;Institute of Chinese Medica,China Academy of Chinese Medical Sciences;Department of Cardiology,Xiyuan Hospital,China Academy of Chinese Medical Sciences;

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