中国中药杂志

2021, v.46(24) 6377-6386

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基于心理应激视角探讨中医七情内伤与乳腺癌发病机制的相关性
Correlation between internal damage due to seven emotions in traditional Chinese medicine and pathogenesis of breast cancer from perspective of psychological stress

刘雪梅;刘慧敏;马乐乐;张定堃;马鸿雁;林俊芝;许润春;
LIU Xue-mei;LIU Hui-min;MA Le-le;ZHANG Ding-kun;MA Hong-yan;LIN Jun-zhi;XU Run-chun;State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine;Traditional Chinese Mdeicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine;

摘要(Abstract):

乳腺癌是严重危害女性健康的一大慢性病,其确诊人数首次超过肺癌,成为全世界常见的癌症类型之一。研究提示七情内伤是导致乳腺癌发病的重要因素,心理应激伴随的下丘脑-垂体-肾上腺(hypothalamus-pituitary-adrenal, HPA)轴和内分泌失调以及免疫防御机制异常均影响乳腺癌的发生、发展。值得关注的是,中医的七情学说与现代医学的心理应激理论在某些方面具有共通之处。因此,该文深入探究七情内伤与心理应激的关联,从现代医学的角度探讨心理应激影响乳腺癌的相关分子生物学机制,有助于通过情绪调节合理预防乳腺癌等相关肿瘤和改善乳腺癌患者的预后。
Breast cancer is a major chronic disease threatening women′s health. It has topped the global cancers as the diagnosed cases outnumbered lung cancer patients in 2020. Internal damage due to the seven emotions is an important cause of breast cancer and the disorders of hypothalamic-pituitary-adrenal(HPA) axis and endocrine system and the abnormal immune defense mechanism in response to psychological stress all affect the occurrence and development of breast cancer. It is noteworthy that the theory of seven emotions in traditional Chinese medicine and the psychological stress theory of modern medicine have something in common in some aspects. Therefore, this study explored the correlation between internal damage due to the seven emotions and psychological stress and analyzed the molecular biological mechanisms of psychological stress influencing breast cancer from the perspective of modern medicine, which is helpful to reasonably prevent breast cancer and other related tumors and improve the prognosis of breast cancer patients through emotion regulation.

关键词(KeyWords): 七情内伤;心理应激;乳腺癌;分子机制
internal damage due to the seven emotions;psychological stress;breast cancer;molecular mechanism

Abstract:

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基金项目(Foundation): 国家自然科学基金面上项目(81873232);; 成都中医药大学中药学学科特色创新科研团队项目(CXTD2018006)

作者(Author): 刘雪梅;刘慧敏;马乐乐;张定堃;马鸿雁;林俊芝;许润春;
LIU Xue-mei;LIU Hui-min;MA Le-le;ZHANG Ding-kun;MA Hong-yan;LIN Jun-zhi;XU Run-chun;State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine;Traditional Chinese Mdeicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine;

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