中国中药杂志

2016, v.41(11) 2144-2148

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外翻肠囊法研究扶正消症方中黄连碱类在大鼠肠内的吸收
Absorption characteristics of alkaloids in Fuzheng Xiaozheng Fang by rat everted intestinal sac models

谢小珂;闫利华;朱晶晶;姚丽;易红;刘晓谦;杨金生;张启伟;王智民;
XIE Xiao-ke;YAN Li-hua;ZHU Jing-jing;YAO Li;YI Hong;LIU Xiao-qian;YANG Jin-sheng;ZHANG Qi-wei;WANG Zhi-min;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences;

摘要(Abstract):

采用大鼠外翻肠囊模型,研究扶正消症方中小檗碱、巴马汀、黄连碱、表小檗碱4种黄连碱在大鼠不同肠段的吸收情况,计算各成分的吸收参数,用SPSS 20.0统计学软件对数据进行分析处理,分析其在不同肠段的吸收特征。结果显示,各生物碱成分在不同肠段的吸收均符合零级吸收速率;4种生物碱成分在低剂量时的吸收速率常数(Ka)与中、高剂量比较有显著性差异(P<0.05),但是中剂量与高剂量比较Ka并没有明显差异。扶正消症方提取物不同剂量时,4个生物碱在不同肠段的吸收方式除被动扩散外还存在主动转运。4个生物碱在回肠中的吸收量略高于空肠,但无显著性差异,表明这4个生物碱在小肠无特定吸收窗。
Everted intestinal sac models were used to investigate the intestinal absorption of the 4 alkaloids( berberine,palmatine,coptisine,and epiberberine) in Fuzheng Xiaozheng Fang( FZ) at different intestine segments. The absorption parameters of each component were calculated; SPSS 20. 0 software was used to analyze the data and evaluate the absorption characteristics at different intestinal segments. The results showed that all the four active ingredients conformed to zero-order absorption rate. There was significant difference in absorption rate constant( K_a) between the four ingredients at low dose and medium and high dose groups( P < 0. 05),but there was no significant difference in K_a between medium dose and high dose. The absorption mechanization of four ingredients presented two absorption manners: positive diffusion and passive absorption. The absorptive amount of 4 alkaloids in ileum was slightly greater than that of jejunum,but no significant differences were observed,which indicated that these four alkaloids had no specific absorption windows in intestinal segment.

关键词(KeyWords): 扶正消症方;小檗碱;巴马汀;黄连碱;表小檗碱;肠外翻
Fuzheng Xiaozheng Fang;berberine;palmatine;coptisine;epiberberine;everted intestinal sac

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2012ZX09103201-027,2012ZX09103201-009);; 中国中医科学院客座研究员联合创新研究项目(ZZ070837)

作者(Author): 谢小珂;闫利华;朱晶晶;姚丽;易红;刘晓谦;杨金生;张启伟;王智民;
XIE Xiao-ke;YAN Li-hua;ZHU Jing-jing;YAO Li;YI Hong;LIU Xiao-qian;YANG Jin-sheng;ZHANG Qi-wei;WANG Zhi-min;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences;

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