中国中药杂志

2008, (22) 2614-2616

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

黄连吴茱萸药对配伍变化对黄连生物碱煎出及其对大鼠小肠吸收的影响
Influence on rat intestinal absorption of huanglian alkalis after match-pair of huanglian-wuzhuyu

孙万晶;张玉杰;姚南;姜昊;汪祺;
SUN Wan-jing,ZHANG Yu-jie,YAO Nan,JIANG Hao,WANG Qi(1.School of Chinese Material Medica,Beijing University of Chinese Medicine,Beijing 100102,China;2.First Hospital,Lanzou University,Lanzhou 730000,China)

摘要(Abstract):

目的:研究吴茱萸对黄连生物碱成分煎出和的大鼠小肠吸收的影响,探讨黄连吴茱萸药对配伍的机理。方法:以HPLC测定黄连生物碱成分含量,采用大鼠非翻转肠囊实验和翻转肠囊实验,考察吴茱萸对黄连生物碱小肠吸收和转运的影响。结果:随吴茱萸配伍比例的增加黄连煎液中生物碱成分含量呈下降的趋势,黄连配伍吴茱萸后可使小肠吸收黄连生物碱作用得到改善,当黄连与吴茱萸配比为6∶1时,黄连生物碱成分的小肠吸收最为明显。结论:黄连吴茱萸配比为6∶1时,吴茱萸促进黄连生物碱的小肠吸收最强,小肠吸收是黄连吴茱萸配伍作用的重要环节。
Objective: To research effect of Wuzhuyu on Huanglian intestinal absorption and to provide some basic principle of match-pair of huanglian-rougui.Method: The rat everted gut sac method as well as non everted gut sac method was applied to investigate the influence of Wuzhuyu on Huanglian intestinal absorption.Result: The content of each alkalis in Huanglian was decreasing with the comptibale ration increase,and the intestinal absorption had been improved in some degree.The intestinal absorption of Huanglian alkalis reached the highest level when match-pair ration of huang Lian-rougui was 6∶1.Conclusion: The chemical reaction in the progress of extraction and the intestinal absorption of huanglian alkalis were the key factors of match-pair of huanglian-wuzhuyu.

关键词(KeyWords): 黄连吴茱萸药对配伍;小肠吸收;黄连生物碱
match-pair of huanglian-wuzhuyu;intestinal absorption;huanglian alkalis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(30672585)

作者(Author): 孙万晶;张玉杰;姚南;姜昊;汪祺;
SUN Wan-jing,ZHANG Yu-jie,YAO Nan,JIANG Hao,WANG Qi(1.School of Chinese Material Medica,Beijing University of Chinese Medicine,Beijing 100102,China;2.First Hospital,Lanzou University,Lanzhou 730000,China)

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享