中国中药杂志

2015, v.40(17) 3416-3422

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肿瘤生物学研究热点与抗肿瘤中药研发策略
Current topics on cancer biology and research strategies for anti-cancer traditional Chinese medicine

陈修平;唐正海;石哲;陆金健;苏焕兴;陈新;王一涛;
CHEN Xiu-ping;TANG Zheng-hai;SHI Zhe;LU Jin-jian;SU Huan-xing;CHEN Xin;WANG Yi-tao;State Key Laboratory of Quality Research in Traditional Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;

摘要(Abstract):

肿瘤生物学研究近年来取得长足进展,肿瘤免疫、肿瘤干细胞、细胞自噬、上皮-间质转化等已成为肿瘤学研究热点。对这些肿瘤生物过程的详尽阐明,为这种多因素导致细胞异常增殖,发病率和死亡率均居重大疾病之首肿瘤疾病治疗,也为抗肿瘤中药的药理评价、原理阐明和创新药研发提供了提供了新的靶标、新的契机与新的研究策略。
Cancer,an abnormal cell proliferation resulted from multi-factors,has the highest morbidity and mortality among all the serious diseases. Considerable progress has been made in cancer biology in recent years. Tumor immunology,cancer stem cells( CSCs),autophagy,and epithelial-mesenchymal transition( EMT) have become hot topics of interests in this area. Detailed dissection of these biological processes will provide novel directions,targets,and strategies for the pharmacological evaluation,mechanism elucidation,and new drug development of traditional Chinese medicine.

关键词(KeyWords): 肿瘤;中药;肿瘤免疫;细胞自噬;肿瘤干细胞;上皮-间质转化
tumor;traditional Chinese medicine;tumor immunology;autophagy;cancer stem cells;epithelial-mesenchymal transition(EMT)

Abstract:

Keywords:

基金项目(Foundation): 澳门科学技术发展基金项目(077/2011/A3);; 澳门大学研究基金项目(CPG2014-00012-ICMS,MYRG2015-00101-ICMS-QRCM)

作者(Author): 陈修平;唐正海;石哲;陆金健;苏焕兴;陈新;王一涛;
CHEN Xiu-ping;TANG Zheng-hai;SHI Zhe;LU Jin-jian;SU Huan-xing;CHEN Xin;WANG Yi-tao;State Key Laboratory of Quality Research in Traditional Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau;

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