中国中药杂志

2000, (07)

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伊犁贝母和梭砂贝母生理活性的初步比较
An Preliminary Comparative Study on Physiological Activity of Fritillaria pallidiflora Schrek.and F.delavayi Franch

徐惠波,孙晓波,温富春,周继胡,丁涛,孙利雯,李瑛
XU Hui bo 1,SUN Xiao bo 1,WEN Fu chun 1,ZHOU Ji hu 1,DING Tao 1,SUN Li wen 1,LI Ying 2 (1.Academy of TCM and Materia Medica of Jilin Province, Changchun 130021,Jilin,China; 2.Jilin Provincial Institute for Drug Control, Changchum 130031, Jil

摘要(Abstract):

目的 :对伊犁贝母总生物碱 (FPA)、梭砂贝母总生物碱 (FDA)生物活性进行初步比较。方法 :采用小鼠二甲苯耳水肿、SO2 引发小鼠咳嗽、酚红法祛痰实验及细菌体外培养等方法。结果 :伊犁贝母和梭砂贝母的总生物碱以 40 0mg·kg-1,2 0 0mg·kg-1剂量一次性灌胃给药 ,具有明显的抗炎、镇咳、祛痰作用 ,伊犁贝母的作用效果在某些方面略强于梭砂贝母 ;在相同生药量下同样表现出前者强于后者的作用效果。伊犁贝母对流感嗜血杆菌、金黄色葡萄球菌、肺炎球菌等多种细菌有不同程度的抑菌作用 ,梭砂贝母与之相比抑菌作用较弱。结论 :伊犁贝母抗炎、镇咳、祛痰、抑菌作用略强于梭砂贝母。
Objective:To compare the physiological activity of Fritillaria pallidiflora alkaloids(FPA)with that of F. delavayi alkaloids(FDA).Method:Xylene induced ear swelling in mice,SO 2 induced cough in mice,expectorant experiment on phenolsulfon phthalein excretion and bacteria incubation in vitro,etc. Result:The total alkaloids of both FPA and FDA(ig,400mg·kg -1 and 200mg·kg -1 )have anti inflammatory,antibechic and expectorant effects,but the former is more effective than the latter.Given the same dosage,FPA is still more effective than FDA.FPA can inhibit Hemophilus influenzae, Staphylococcus aureus and Streptococcus pneumoniae,etc,more effectively than FDA.Conclusion:In anti inflammatory,antibechic,expectorant and bacteriostatic effects FPA is superior to FDA. [

关键词(KeyWords): 伊犁贝母;梭砂贝母;抗炎;止咳;祛痰
Fritillaria pallidiflora;F.delavayi; anti inflammatory;antibechic;expectorant

Abstract:

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基金项目(Foundation): 国家自然科学基金资助项目!( 3 93 0 0 170 )

作者(Author): 徐惠波,孙晓波,温富春,周继胡,丁涛,孙利雯,李瑛
XU Hui bo 1,SUN Xiao bo 1,WEN Fu chun 1,ZHOU Ji hu 1,DING Tao 1,SUN Li wen 1,LI Ying 2 (1.Academy of TCM and Materia Medica of Jilin Province, Changchun 130021,Jilin,China; 2.Jilin Provincial Institute for Drug Control, Changchum 130031, Jil

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