中国中药杂志

2007, (10) 912-915

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大孔吸附树脂分离纯化莲心生物碱
Separation and purification processes of alkaloids from Lotus plumule with macroporous adsorption resin

刘韶;雷鹏;李新中;陈英华;
LIU Shao,LEI Peng,LI Xin-zhong,CHEN Ying-hua(Department of Pharmacy of Xiangya Hospital,Center South University, Hunan 410008,China)

摘要(Abstract):

目的:用大孔吸附树脂对莲心生物碱进行分离纯化研究。方法:以吸附量、洗脱率及甲基莲心碱的含量为考察指标,选择纯化工艺。结果:LSA-5B型大孔吸附树脂对莲心生物碱具有较大吸附量。最佳吸附条件是:上样液质量浓度在0.125 g.mL-1(相当于原生药),洗脱方法为先以纯化水除去杂质,再以50%乙醇洗脱,收集50%乙醇洗脱部分。结论:该法简单可行,适合工业生产。
Objective: To explore the optimal separation of the alkaloids from Lotus plumule by selecting appropriate macroporous adsorption resins.Method: To evaluated the separating efficiency by measuring the adsorption ratio,eluting ratio and the concentration of neferine.Result: The LSA-5B macroporous adsorption resin prolided the optimal separating efficiency.The best adsorption capacity was achieved with the following conditions:the concentration of extact liquid was 0.125 g·mL-1(equivalence to raw material),then the resin was washed by water to remove impurity and alkaloids were desorbed by 50% ethanol.Conclusion: This method is simple,feasible and suitable for industry production.

关键词(KeyWords): 大孔吸附树脂;莲心;生物碱
macroporous adsorption resin;Lotus plumule;alkaloids

Abstract:

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基金项目(Foundation): 湖南省科技厅项目(05JT1081)

作者(Author): 刘韶;雷鹏;李新中;陈英华;
LIU Shao,LEI Peng,LI Xin-zhong,CHEN Ying-hua(Department of Pharmacy of Xiangya Hospital,Center South University, Hunan 410008,China)

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