中国中药杂志

2022, v.47(18) 4966-4971

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龙葵成熟果中2个新生物碱
Two new steroidal alkaloids from ripe berries of Solanum nigrum

杨宇珂;刘良裕;王文义;王建农;林力;刘建勋;
YANG Yu-ke;LIU Liang-yu;WANG Wen-yi;WANG Jian-nong;LIN Li;LIU Jian-xun;Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences;College of Pharmacy, Fujian University of Traditional Chinese Medicine;

摘要(Abstract):

对茄科茄属植物龙葵Solanum nigrum成熟果实中的生物碱类成分进行研究,采用硅胶、ODS和HPLC等色谱技术从龙葵成熟果80%乙醇提取物中共分离得到4个化合物,根据理化性质和波谱数据鉴定了化合物的结构,分别为12β,27-dihydroxy solasodine-3-O-β-D-glucopyranoside(1)、27-hydroxy solasodine-3-O-β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside(2)、solalyraine A(3)和12β,27-dihydroxy solasodine(4)。其中化合物1和2为新化合物,化合物3为首次从该植物中分离得到。对所分离新化合物进行了抗肿瘤活性研究,结果显示化合物1和2对A549细胞系有较弱的细胞毒性。
Two previously undescribed steroidal alkaloids, compounds 1-2, along with two known ones(3-4), were isolated from the 80% ethanol extract of ripe berries of Solanum nigrum by chromatographic methods, including silica gel, ODS, and HPLC. Based on spectroscopic and chemical evidence, including IR, NMR, and HR-ESI-MS data, the structures of the isolated compounds were identified as 12β,27-dihydroxy solasodine-3-O-β-D-glucopyranoside(1), 27-hydroxy solasodine-3-O-β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside(2), solalyraine A(3), and 12β,27-dihydroxy solasodine(4). Compounds 1-2 were tested for their potential effects against the proliferation of A549 cells, which revealed that compounds 1-2 had weak cytotoxic activity.

关键词(KeyWords): 龙葵;甾体生物碱;化学成分;抗肿瘤活性
Solanum nigrum;steroidal alkaloid;chemical constituent;antitumor activity

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 杨宇珂;刘良裕;王文义;王建农;林力;刘建勋;
YANG Yu-ke;LIU Liang-yu;WANG Wen-yi;WANG Jian-nong;LIN Li;LIU Jian-xun;Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences;College of Pharmacy, Fujian University of Traditional Chinese Medicine;

DOI: 10.19540/j.cnki.cjcmm.20220506.205

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