中国中药杂志

2015, v.40(22) 4351-4354

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自噬与2型糖尿病的关系及中药的干预作用
Relationship between autophagy and T2DM and intervention effect of traditional Chinese medicine

洪金妮;黎巍威;王学美;
HONG Jin-ni;LI Wei-wei;WANG Xue-mei;Integrated Laboratory of Traditional Chinese Medicine and Western Medicine,Peking University First Hospital;

摘要(Abstract):

胰岛素抵抗(insulin resistance,IR)和胰岛β细胞分泌功能缺陷是诱导2型糖尿病(type 2 diabetes mellitus,T2DM)发生的主要机制,而线粒体受损是参与IR和胰岛β细胞损伤的重要环节,研究显示自噬作为一种细胞的自我保护机制,在维持胰岛β细胞结构和功能、改善IR等方面发挥着重要作用。近期研究表明中药可通过调节细胞自噬,进而改善胰岛β细胞和胰岛素抵抗,对2型糖尿病及其并发症起到防治作用。该文将就自噬与2型糖尿病的关系及中药的干预作用的研究进展做综述。
Insulin resistance and insulin secretion deficiency are main machanisms in inducing type 2 diabetes mellitus( T2DM),and mitochondria damage plays an important role in them. Research shows that autophagy is a self-protective mechanism of cells,which plays an important role in maintaining the normal structure and function of pancreatic β cells and improving insulin resistance. Previous studies show that traditional Chinese medicine can regulate cell autophagy to influence β cells and insulin resistance,type 2 diabetes mellitus and its complications. Thus this review will talk about the process of the relationship between autophagy and T2 DM and the intervention effect of traditional Chinese medicine.

关键词(KeyWords): 自噬;2型糖尿病;并发症;中医药
autophagy;type 2 diabetes mellitus;complication;traditional Chinese medicine

Abstract:

Keywords:

基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2009CB523003);; 北京科技计划项目(D131100004713004)

作者(Authors): 洪金妮;黎巍威;王学美;
HONG Jin-ni;LI Wei-wei;WANG Xue-mei;Integrated Laboratory of Traditional Chinese Medicine and Western Medicine,Peking University First Hospital;

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