中国中药杂志

2008, (07) 851-853

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论中药复方药效研究
Discuss of efficacy study to traditional Chinese medicine complex prescription

郭丽丽;王阶;
GUO Li-li,WANG Jie(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

摘要(Abstract):

中医药学与西医药学之间存在多种差异,在中医药理论指导下应用的中药有其自己的特点。辨证论治是遣方用药的基础,配伍用药是中药应用的主要形式,方证相应是中药取效的关键,整合调节是中药的作用方式。上述特点决定了中药药效评价不能照搬西药的方法和标准。运用现代技术和中药自身特点建立中药疗效评价方法和标准体系是正确评价中药疗效的关键。质量稳定是药效评价的前提,病证结合动物模型是疗效评价必不可少的工具,整合调节的作用方式要求药效指标的选择要多样化,避免主观误差的手段是利用数学模型和参数对数据进行科学分析,作用机制的阐明还需要规范的临床药理实验提供数据。
There are many differences between traditional Chinese medicine(TCM)and western medicine,and the use of TCM has its feature under the guide of TCM theory.Determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is the base of TCM treatment,the main form of TCM apply is compatibility,formula corresponding differentiation of symptoms and signs is the key for TCM to get better effects,integrated adjustment is the TCM mode of action.All above determined the methods and standards to evaluate the pharmacodynamic effect of TCM cannot completely accord to Western medicine.Use modern technology and combine the feature of TCM to estabilish the method for effects evaluation and standard system of TCM,which is the key point to correctly appraise the effects of TCM.Stabilized quality control is the precondition of pharmacodynamic action appraisement,animal models combined disease and symptoms are the necessary tools for effect appraisement,integrated adjustment need mutiple index to appraise pharmacodynamic action,the method to avoid subjective error in TCM reseach is using mathematical model and parameter to scientificly analyse data,also the explaination of mechanism of action need standard clinical pharmacology experimental date.

关键词(KeyWords): 中药特点;药效评价
character of traditional Chinese medicine;pharmacodynamic appraisement

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基金项目(Foundation): 国家自然科学基金重大项目(90209011);; 国家重点基础研究发展计划(973)项目(2003CB517103)

作者(Author): 郭丽丽;王阶;
GUO Li-li,WANG Jie(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

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