中国中药杂志

2008, (06) 680-682

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委陵菜抗糖尿病有效部位及有效成分的研究
Study on anti-diabetes active fraction and constituents from Potentilla chinesis

赵川;乔卫;张彦文;卢滨;段宏泉;
ZHAO Chuan,QIAO Wei,ZHANG Yan-wen,LU Bin,DUAN Hong-quan (School of Pharmaceutical Sciences,Tianjin Medical University,Tianjin 300070,China)

摘要(Abstract):

目的:以四氧嘧啶模型小鼠结合提取分离方法鉴定委陵菜降血糖的有效部位及有效成分。方法:将委陵菜的95%乙醇提取物用不同极性的溶剂萃取得到各提取部位,以四氧嘧啶糖尿病小鼠模型考察各部位的抗糖尿病作用,并对其中抗糖尿病最强的部位进一步分离纯化,进一步检测化合物的抗糖尿病作用。结果:委陵菜F部位与委陵菜黄酮给药后与模型组均有显著性差异(P<0.01),说明委陵菜F部位与委陵菜黄酮具有明显的降低四氧嘧啶糖尿病小鼠血糖的作用,委陵菜黄酮降血糖作用强于阳性对照药盐酸苯乙双胍。结论:F部位是委陵菜降血糖的有效部位,委陵菜黄酮是委陵菜降血糖的有效成分。
Objective: To study the active fraction and constituents from Potentilla chinesis.Method: Tested fractions were obtained by different solvent-partition from 95% ethanol-extracts of P.chinesis,and tested compound was isolated by repeated chromatography.Anti-diabetes experiment was taken by using alloxan-induced diabetic mice.Result: The fraction F and the tested compound revealed obvious difference comparing with the control group(P<0.01).Conclusion: Fraction F and potentilla flavone revealed the significant hypoglycemic effect in alloxan-induced diabetic mice.

关键词(KeyWords): 委陵菜;抗糖尿病作用;有效部位;委陵菜黄酮
Potentilla chinesis;anti-diabetes effect;active fraction;potentilla flavone

Abstract:

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基金项目(Foundation): 天津市科技应用基础研究重点基金项目(07JCZDJC05100)

作者(Author): 赵川;乔卫;张彦文;卢滨;段宏泉;
ZHAO Chuan,QIAO Wei,ZHANG Yan-wen,LU Bin,DUAN Hong-quan (School of Pharmaceutical Sciences,Tianjin Medical University,Tianjin 300070,China)

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