中国中药杂志

1999, (02) 3-5

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牛磺胆酸钠在不同介质中及灭菌过程中的稳定性研究
Studies on the Stability of Sodium Taurocholate in Different Media and in the Course of Sterilization

刘莹莹,石朝周,胡永祥,郑子川,陆小红
Liu Yingying,Shi Chaozhou,Hu Yongxiang,Zheng Zichuan and Lu Xiaohong (School of Pharmacy,Tongji Medical University,Wuhan 430030)

摘要(Abstract):

目的:考察蛇胆主要有效成分牛磺胆酸钠在25%乙醇液中和人工胃液中及其在热压灭菌过程中的稳定性。方法:该溶液的稳定性预测采用恒温加速试验法,其含量测定借助薄层比色法。结果:25℃时牛磺胆酸钠在25%乙醇液中的半衰期(t1/2)为60.57d;37℃时在人工胃液中的半衰期为11.37d;其水溶液在115℃,30min灭菌条件下,牛磺胆酸钠损失率为3%。结论:牛磺胆酸钠在25%乙醇水溶液中不稳定。建议增大乙醇浓度,并将其贮藏在0℃以下
Objective:To investigate the stability of the main active constituent of snake gall sodium taurocholate,TCANa in 25% alcoholic solution and artificial gastric juice,and in the course of hot pressurized sterilization.Method:The stability of the solution was predicted by an accelerated isothermal test,and the content of TCANa was determined by TLC colorimetery.Result:The half time(tl/2)of TCANa in 25% alcoholic solution is 60.57d at 25℃,and in artificial gastric juice 11.37d at 37℃,the loss rate under the condition(115℃,30min)of sterilization about 3%.Conclusion:TCANa in 25% alcoholic solution is unstable.Therefore it is suggesed that in order to raise the stability of TCANa the alcoholic concentration be increased and the solution be stored at temperatures below 0℃.

关键词(KeyWords): 蛇胆,稳定性,结合胆汁酸,牛磺胆酸钠
snake gall;stability;conjugated bile acids;sodium taurocholate

Abstract:

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基金项目(Foundation): 国家自然科学基金

作者(Author): 刘莹莹,石朝周,胡永祥,郑子川,陆小红
Liu Yingying,Shi Chaozhou,Hu Yongxiang,Zheng Zichuan and Lu Xiaohong (School of Pharmacy,Tongji Medical University,Wuhan 430030)

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