中国中药杂志

2019, v.44(02) 308-313

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3种辛味中药挥发油对苦参生物碱类成分透皮吸收的影响
Effects of pungent essential oil from three Chinese herbs on percutaneous absorption of alkaloids from Sophorae Flavescentis Radix

王玲;张婷;钱大玮;朱振华;王春雪;翁泽斌;张黄琴;郭盛;宿树兰;段金廒;
WANG Ling;ZHANG Ting;QIAN Da-wei;ZHU Zhen-hua;WANG Chun-xue;WENG Ze-bin;ZHANG Huang-qin;GUO Sheng;SU Shu-lan;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine;National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Ch

摘要(Abstract):

研究薄荷、苍术、蛇床子3种辛味药材挥发油对苦参喹诺里西啶类生物碱成分体外透皮吸收的影响。采用立式改良型Franz扩散池,以离体SD大鼠腹部皮肤为透皮吸收屏障进行体外透皮实验,采用UPLC-TQ-MS测定透皮接收液中氧化苦参碱、氧化槐果碱、N-甲基金雀花碱、槐定碱、苦参碱、槐果碱6种喹诺里西啶类生物碱的含量,考察3种挥发油对苦参生物碱类成分透皮吸收的影响。不同质量分数(1%,3%,5%)的3种挥发油对苦参喹诺里西啶类生物碱成分均有透皮促渗作用,促透效果(以ER为指标):1%苍术油>1%蛇床子油>3%氮酮≈3%苍术油>5%苍术油>3%蛇床子油≈5%蛇床子油>3%薄荷油>5%薄荷油>1%薄荷油>空白。结果表明3种挥发油均可作为苦参喹诺里西啶类生物碱成分的促渗剂,为苦参生物碱类成分透皮吸收制剂的研制提供参考。
To investigate the effects of essential oil from three kinds of pungent herbs,namely Menthae Haplocalycis Herba,Atractylodis Rhizoma and Cnidii Fructus,on the transdermal absorption in vitro of alkaloids from Sophorae Flavescentis Radix. The modified vertical Franz diffusion cell was used to conduct a transdermal experiment in vitro with the isolated abdominal skin of the SD rats as the transdermal absorption barrier. The effects of such three kinds of pungent essential oil on percutaneous absorption of alkaloids from Sophorae Flavescentis Radix were investigated by determining the content of 6 alkaloids( oxymatrine,oxysophocarpine,N-methylcytisine,sophoridine,matrine,and sophocarpidine) in the transdermal acceptor with ultra-performance liquid chromatography-triple quadruple mass spectrometry( UPLC-TQ-MS) technique simultaneously. With enhancement ratio( ER) as the index,their effects on promoting penetration was as follows: 1% Atractylodis Rhizoma oil > 1% Cnidii Fructus oil > 3% Azone ≈ 3% Atractylodis Rhizoma oil > 5%Atractylodis Rhizoma oil > 3% Cnidii Fructus oil ≈ 5% Cnidii Fructus oil > 3% Menthae Haplocalycis Herba oil > 5% Menthae Haplocalycis Herba oil > 1% Menthae Haplocalycis Herba oil > Blank. The results showed that these three kinds of pungent essential oil could be used as enhancers for alkaloids of Sophorae Flavescentis Radix,providing scientific guidance for improving percutaneous absorption of alkaloids from Sophorae Flavescentis Radix.

关键词(KeyWords): 辛味中药;挥发油;苦参;生物碱;透皮吸收
pungent herbs;essential oil;Sophorae Flavescentis Radix;alkaloids;percutaneous absorption

Abstract:

Keywords:

基金项目(Foundation): 宁夏回族自治区重点研发计划(东西部科技合作)项目(2017BY079)

作者(Author): 王玲;张婷;钱大玮;朱振华;王春雪;翁泽斌;张黄琴;郭盛;宿树兰;段金廒;
WANG Ling;ZHANG Ting;QIAN Da-wei;ZHU Zhen-hua;WANG Chun-xue;WENG Ze-bin;ZHANG Huang-qin;GUO Sheng;SU Shu-lan;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine;National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Ch

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DOI: 10.19540/j.cnki.cjcmm.20181108.001

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