中国中药杂志

2016, v.41(03) 438-442

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

响应面法优化泽泻中23-乙酰泽泻醇B闪式提取工艺
Optimization of flash-type extraction technology of alisol B 23-acetate from Alismatis Rhizoma by response surface methodology

韦迎春;闫明;杨晶;刘俊超;殷洪梅;吴云;孙永城;萧伟;
WEI Ying-chun;YAN Ming;YANG Jing;LIU Jun-chao;YIN Hong-mei;WU Yun;SUN Yong-cheng;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

摘要(Abstract):

采用响应面分析法优化得到23-乙酰泽泻醇B闪式提取的最佳工艺。采用单因素考察法,以23-乙酰泽泻醇B提取率为指标,考察乙醇浓度、液料比、提取次数、提取时间对23-乙酰泽泻醇B提取率的影响,并结合Box-Behnken试验设计和响应面分析方法对闪式提取泽泻的工艺参数进行优化,得到23-乙酰泽泻醇B闪式提取最佳工艺为80%乙醇、液料比12∶1、提取4次、提取时间114 s/次。通过响应面法优化得到的23-乙酰泽泻醇B闪式提取工艺,稳定、省时、高效,且具有可室温提取、无成分破坏的优点,可用于实际大生产。
Response surface methodology was used to optimize and obtain the optimal flash-type extraction technology of alisol B 23-acetate from Alismatis Rhizoma. With the extraction rate of alisol B 23-acetate as an indicator,single-factor test was used to investigate the effect of ethanol volume fraction,liquid-solid ratio,extraction times and extracting time on the extraction rate of alisol B 23-acetate. The results were combined with Box-Benhnken design and response surface analysis to optimize the technology parameters for extraction process of Alismatis Rhizoma and obtain the optimal flash-type extraction technology under the following conditions: ethanol volume fraction 80%,liquid-solid ratio 12∶ 1,extraction 4 times,114 s / time. Flash-type extraction technology of alisol B 23-acetate by response surface methodology is stable,time-saving,efficient,and with the advantages of room temperature extraction and no component damage,so it can be used for massive production.

关键词(KeyWords): 23-乙酰泽泻醇B;闪式提取;响应面法
alisol B 23-acetate;flash-type extraction;response surface methodology

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 韦迎春;闫明;杨晶;刘俊超;殷洪梅;吴云;孙永城;萧伟;
WEI Ying-chun;YAN Ming;YANG Jing;LIU Jun-chao;YIN Hong-mei;WU Yun;SUN Yong-cheng;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享