中国中药杂志

2002, (10)

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薄荷脑和冰片挥发性的动力学研究
Kinetic Study on the Volatility of Menthol and Borneol

邹节明,王力生,文晖,王淑霖
ZOU Jie-ming, WANG Li-sheng, WEN Hui, WANG Shu-lin (Guilin Sanjin Pharmaceutical Co.Ltd., Guilin 541004,Guangxi,China)

摘要(Abstract):

目的 :研究不同温度下颗粒和素片中薄荷脑和冰片的散逸规律。方法 :GC和化学动力学法。结果 :颗粒和素片中的薄荷脑和冰片在开放体系中的散逸均符合化学动力学的一级反应 ;在相同条件下 ,薄荷脑和冰片在颗粒中的逸散速度较片剂快约 4倍 ,并且冰片的逸散速度较薄荷脑稍快。结论 :对同类产品的生产和稳定性研究有一定参考价值。
Objective: To study the volatile regularity of menthol and borneol in granule and lozenge at different temperature. Method: Kinetic method with GC being detection technique. Result: The volatility of menthol and borneol acts as a pseudo first-order reaction in open system. Under the same condition, the volatile rate of menthol and borneol in granule is four times as fast as that in lozenge, and the volatile rate of borneol is faster than that of menthol. Conclusion: This study can be applied to improve the quality of lozenges containing menthol or/and borneol.

关键词(KeyWords): 薄荷脑;冰片;动力学;散逸速率
menthol; borneol; kinetics; volatility

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作者(Author): 邹节明,王力生,文晖,王淑霖
ZOU Jie-ming, WANG Li-sheng, WEN Hui, WANG Shu-lin (Guilin Sanjin Pharmaceutical Co.Ltd., Guilin 541004,Guangxi,China)

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