中国中药杂志

2013, v.38(16) 2721-2727

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基于生物网络探讨防治冠心病药物作用机制
Action mechanism of drugs for preventing and treating coronary heart disease based on biological networks

张燕玲;黄明峰;乔延江;
ZHANG Yan-ling,HUANG Ming-feng,QIAO Yan-jiang*(Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine,Beijing 100102,China)

摘要(Abstract):

该文以冠心病疾病相关基因和靶点以及防治冠心病药物作用靶点为研究对象,分别构建冠心病疾病网络和防治冠心病药物作用网络,并对网络的度分布、特征路径长度、连通情况和异质性等网络拓扑特征参数进行分析,验证了网络的可靠性;在此基础上对2个网络取Intersection计算,对二者的交集子网络进行药物作用机制解析。所构建的冠心病疾病网络含有15 221个节点和31 177条边、防治冠心病药物作用网络含有15 073个节点和32 376条边,2个网络的拓扑特征参数表明均具有无标度和小世界的整体结构特性。本文以交集子网络中降钙素基因相关肽和IL-6激活JAK/STAT 2个反应途径为例,探讨阐释了药物防治冠心病的间接作用机制。研究结果表明将疾病网络与药物作用网络相互结合的生物网络分析方法有助于进一步深入认识药物治疗的作用机制,对于疾病的预防和治疗具有重要价值。
Coronary heart disease(CHD) related genes and targets,as well as drug targets for preventing and treating CHD were taken as the study objects to build a CHD disease network and a drug action network preventing and treating CHD.Such topological characteristic parameters of the networks as degree distribution,characteristic path length,connectivity and heterogeneity were analyzed to verify the reliability of the networks.On that basis,the intersection calculation was conducted for both networks to analyze the drug action mechanism of their sub-networks.The disease network are composed of 15,221 nodes and 31,177 sides,while the drug action network preventing and treating CHD has 15,073 nodes and 32,376 sides.Both of their topological characteristic parameters showed scale-free small world structural characteristics.Two reaction pathways in the sub-networks—calcitonin gene-related peptide and IL-6 activated JAK/STAT were taken as examples to discuss the indirect action mechanism for preventing and treating CHD.The results showed that the biological network analysis method combining the disease network and the drug action network is helpful to further studies on the action mechanism of the drugs,and significant to the prevention and treatment of diseases.

关键词(KeyWords): 冠心病;疾病网络;药物作用网络;网络特征;作用机制
coronary heart disease;disease network;drug action network;network characteristics;action mechanism

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基金项目(Foundation): 国家科技支撑计划项目(2008BAI51B01);; 国家自然科学基金项目(81173522)

作者(Author): 张燕玲;黄明峰;乔延江;
ZHANG Yan-ling,HUANG Ming-feng,QIAO Yan-jiang*(Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine,Beijing 100102,China)

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