中国中药杂志

2008, v.33(23) 2727-2732

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淫羊藿苷药理作用研究进展
Progress of pharmacological research on icariin

李娌;王学美;
LI Li,WANG Xue-mei(Department of Integrated Chinese and Western Medicine,First Hospital,Peking University,Beijing 100034,China)

摘要(Abstract):

淫羊藿苷是一种黄酮类化合物,在体内分布较为广泛,可通过血脑屏障。单体状态时符合开放型二室模型。复方状态时,复方中的其他成分对ICA有促进吸收和分布。体内主要代谢产物为其苷元。以往有大量关于淫羊藿苷对免疫系统、肿瘤组织以及生殖、内分泌系统作用的研究,证实了其强大的药理活性。近年来对于淫羊藿苷的药理研究集中在其对骨组织、心血管系统和神经系统作用等机制方面。
Icariin(ICA),as one of the flavones compounds,possess strong pharmacological effects.With wide body distribution,it even could pass through blood-brain barrier into brain tissues.When intaken as a pure compound,distribution of ICA in body was accord with open type of two compartment model.If it is one ingredient of a complex prescription,other component of these could promote the absorption and distribution of ICA.After metabolism,the main component left was its aglycone.A lot of research about ICA based on immunology,phymatology,genesiology and endocrinology sustained it was a valuable compounds.Recently more research about ICA concentrated their interesting to its mysterious effect on bone tissues,cardiovascular system and especially nervous systems.

关键词(KeyWords): 淫羊藿苷;免疫系统;肿瘤;神经系统
icariin;immune system;tumor;nervous systems

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(30672760);; 教育部博士点基金项目(20070001707)

作者(Authors): 李娌;王学美;
LI Li,WANG Xue-mei(Department of Integrated Chinese and Western Medicine,First Hospital,Peking University,Beijing 100034,China)

参考文献(References):

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