中国中药杂志

2021, v.46(04) 810-819

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经典名方厚朴温中汤的物质基准量值传递分析
Analysis on quality value transmitting of substance benchmark of Houpo Wenzhong Decoction

张晴;罗菊元;胡文均;申若男;刘雪纯;赵玥瑛;黄星月;王昌海;张泽康;陆洋;韩宁;周文艳;
ZHANG Qing;LUO Ju-yuan;HU Wen-jun;SHEN Ruo-nan;LIU Xue-chun;ZHAO Yue-ying;HUANG Xing-yue;WANG Chang-hai;ZHANG Ze-kang;LU Yang;HAN Ning;ZHOU Wen-yan;Beijing University of Chinese Medicine,School of Chinese Materia Medica;Shenzhen Research Institute Beijing University of Chinese Medicine;Yifan Pharmaceutical Co.,Ltd.;

摘要(Abstract):

通过制备15批厚朴温中汤物质基准冻干粉样品,测定其特征图谱、指标成分含量及出膏率,明确特征峰的归属及其与对照图谱的相似度范围,厚朴酚、橙皮苷、甘草酸、乔松素的含量范围及转移率范围,出膏率范围及变化幅度范围等。结果表明物质基准特征图谱与15批物质基准生成的对照图谱R的相似度大于0.90;明确除茯苓外其余药味在全方特征图谱中特征峰的归属,共归属19个特征峰,经对照品指认12个特征峰信息,其中,4个来自姜厚朴、5个来自橘红、2个来自木香、3个来自炙甘草、4个来自草豆蔻、1个来自干姜、生姜; 15批物质基准指标成分含量范围及转移率范围分别为橙皮苷0.80%~1.14%,20.25%~39.61%,甘草酸0.49%~0.79%,23.09%~33.87%,乔松素0.03%~0.07%,3.55%~10.09%,厚朴酚0.15%~0.38%,8.08%~24.35%;出膏率范围及出膏率变化幅度分别为22.60%~25.57%,12.67%~23.68%。该研究引入特征图谱、指标成分含量、出膏率等概念,探索厚朴温中汤物质基准量值传递关系,初步拟定厚朴温中汤物质基准的质量标准,为类似方剂的开发研究提供思路。
By preparing 15 batches of lyophilized powder samples of substance benchmark in Houpo Wenzhong Decoction,the fingerprint,index component content and extract rate were determined,and the characteristic peaks,the range of similarity with the reference map,the content range and transfer rate range of magnolol,hesperidin,glycyrrhizic acid and pinocembrin,the extract rate range and the change range were clarified. The results showed that the similarity between the fingerprint of substance benchmark and the reference map R generated from the 15 batches of substance benchmark samples was higher than 0. 90. The assignment of the characteristic peaks in the full prescription's fingerprint of the herbs except Poria cocos was clarified. Nineteen characteristic peaks were assigned,and 12 characteristic peaks were assigned by the reference substance,of which 4 were from Magnolia ocinalis Cortex,5 from Exocarpium Citri Rubrum,2 from Radix aucklandiae,3 from Glycyrrhiza Radix et Rhizoma,4 from Semen Alpiniae Katsumadai,and one from Rhizoma Zingiberis and Zingiber officinale Roscoe. The index component content range and transfer rate range were 0. 80%-1. 14% and 20. 25%-39. 61% for hesperidin,0. 49%-0. 79% and 23. 09%-33. 87%for glycyrrhizic acid,0. 03%-0. 07% and 3. 55%-10. 09% for pinocembrin,0. 15%-0. 38% and 8. 08%-24. 35% for magnolol. The extract rate range and the change range were22. 60%-25. 57% and 12. 67%-23. 68% respectively. In this study,we introduced the concepts of index component content,fingerprint,extract rate,explored the transfer relation of quality value transmitting of substance benchmark in Houpo Wenzhong Decoction,and initially established the quality standard of Houpo Wenzhong Decoction,all of which would provide ideas for the development and research of similar prescriptions.

关键词(KeyWords): 经典名方;厚朴温中汤;物质基准;特征图谱;量值传递
classical prescription;Houpo Wenzhong Decoction;substance benchmark;characteristic spectrum;quality value transmitting

Abstract:

Keywords:

基金项目(Foundation): 中央高校基本科研业务费专项(2020-JYB-ZDGG-031)

作者(Author): 张晴;罗菊元;胡文均;申若男;刘雪纯;赵玥瑛;黄星月;王昌海;张泽康;陆洋;韩宁;周文艳;
ZHANG Qing;LUO Ju-yuan;HU Wen-jun;SHEN Ruo-nan;LIU Xue-chun;ZHAO Yue-ying;HUANG Xing-yue;WANG Chang-hai;ZHANG Ze-kang;LU Yang;HAN Ning;ZHOU Wen-yan;Beijing University of Chinese Medicine,School of Chinese Materia Medica;Shenzhen Research Institute Beijing University of Chinese Medicine;Yifan Pharmaceutical Co.,Ltd.;

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DOI: 10.19540/j.cnki.cjcmm.20201130.302

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