中国中药杂志

2021, v.46(04) 820-829

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经典名方真武汤的物质基准量值传递分析
Analysis on quality value transfer of substance benchmarks of Zhenwu Decoction

张钰明;杜守颖;白洁;陆洋;韩宁;
ZHANG Yu-ming;DU Shou-ying;BAI Jie;LU Yang;HAN Ning;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

摘要(Abstract):

通过制备15批真武汤物质基准,测定其特征图谱、指标成分含量及出膏率,明确其特征图谱的峰归属、相似度范围、出膏率范围、芍药苷和6-姜辣素的含量范围以及转移率范围。结果表明,物质基准特征图谱与15批物质基准生成的对照图谱R的相似度大于0.970;共归属19个特征峰,进一步汇总特征峰信息可知,茯苓有3个特征峰,白芍有10个特征峰,白术有3个特征峰,生姜有1个特征峰,附子有3个特征峰,其中白芍与附子有1个共有峰; 15批物质基准指标成分含量及转移率分别为芍药苷0.50%~0.93%,16.11%~26.20%; 6-姜辣素0.018 2%~0.033 9%,13.16%~24.10%;出膏率为10.00%~14.85%。该研究通过考察特征图谱、出膏率及指标成分含量,对经典名方真武汤物质基准的量值传递过程进行分析,初步建立了科学稳定的物质基准质量评价方法,为经典名方真武汤的后续开发及相关制剂的质量控制提供依据。
By preparing 15 batches of Zhenwu Decoction substance benchmarks,the characteristic map,index component content and paste-forming rate were determined to define the peak attribution,similarity range,paste-forming rate range,paeoniflorin and6-gingerol content range and transfer rate range. The similarity between the substance benchmark characteristic map and the control map R generated from the 15 batches of substance benchmarks was higher than 0. 970. There were 19 characteristic peaks in total. By further summarization of the characteristic peaks,it could be seen that tuckahoe had 3 characteristic peaks,white peony root had 10 characteristic peaks,atractylodes had 3 characteristic peaks,ginger had 1 characteristic peak,and Aconite root had 3 characteristic peaks; among them,white peony root and aconite root had 1 common peak. The contents and transfer rates of the 15 batches were0. 50%-0. 93 and 16. 11%-26. 20%; those for 6-gingerol were 0. 018 2%-0. 033 9% and 13. 16%-24. 10%,respectively. The pasteforming rate ranged from 10. 00% to 14. 85%. In this study,the transfer process of substance benchmark value of classic formula Zhenwu Decoction was analyzed based on the characteristic map,the paste-forming rate and the content of the index components; a scientific and stable substance benchmark quality evaluation method was preliminarily established to provide a basis for subsequent development of classic formula Zhenwu Decoction and quality control of relevant preparations.

关键词(KeyWords): 经典名方;真武汤;物质基准;特征图谱;量值传递
classical prescription;Zhenwu Decoction;substance benchmarks;characteristic spectrum;quantity value transfer

Abstract:

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基金项目(Foundation): 国家自然科学基金项目(81803737)

作者(Author): 张钰明;杜守颖;白洁;陆洋;韩宁;
ZHANG Yu-ming;DU Shou-ying;BAI Jie;LU Yang;HAN Ning;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

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DOI: 10.19540/j.cnki.cjcmm.20201118.301

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