中国中药杂志

2021, v.46(24) 6387-6394

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中药调节肠道菌群与代谢产物改善高尿酸血症研究进展
Research progress on anti-hyperuricemia effects and mechanisms of Chinese medicines based on regulation of intestinal flora and metabolites

文馨月;唐雪阳;何丹;张海潮;张水寒;曾宏亮;
WEN Xin-yue;TANG Xue-yang;HE Dan;ZHANG Hai-chao;ZHANG Shui-han;ZENG Hong-liang;Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine;Center of Science and Technology Innovation, Hunan University of Chinese Medicine;

摘要(Abstract):

高尿酸血症(hyperuricemia, HUA)是一种由于嘌呤代谢异常或尿酸排泄减少所致的代谢性疾病,以血尿酸(serum uric acid, SUA)、尿氮素(blood urea nitrogen, BUN)和肌酐(serum creatinine, SCr)水平升高等为主要临床特征,长期高尿酸血症与痛风性关节炎、糖尿病、高血压以及肾脏损伤等多种疾病的患病风险增加密切相关,因此控制血尿酸水平可能是延缓和防治高尿酸血症及合并症进程的有效措施。中医药以整体辨证论治观为基础,具有一药多效、作用靶点广泛的优势,在高尿酸血症的治疗中具有很高的应用价值;近年来,肠道微生物及代谢产物调控成为代谢性疾病领域的研究热点,随着对肠道微生物研究的不断深入,发现中药通过多种途径参与肠道菌群及代谢产物调控并改善高尿酸血症,该文从中药活性成分、单味中药及中药复方调节肠道菌群及代谢产物角度,对其抗高尿酸血症的作用与机制研究进展进行综述,以期为中医药抗高尿酸血症研究提供参考。
Chronical hyperuricemia, a severe metabolic disease characterized by increased serum uric acid, urea nitrogen, and creatinine, has a positive correlation with the risks of gouty arthritis, diabetes, hypertension, and kidney damage. Abnormal purine metabolism and reduced uric acid excretion are the major causes of hyperuricemia, which, thus, points to a potential strategy of preventing from or delaying the progress of hyperuricemia-related diseases and its complications by effectively controlling the serum uric acid level. Increasing evidence has revealed that Chinese medicines alleviate hyperuricemia through regulating intestinal flora, which plays a pivotal role in regulating metabolites, including uric acid level. The disease treatment with traditional Chinese medicine is based on syndrome differentiation, and Chinese medicines often have multiple effects and a wide range of targets. In this review, we summarized the anti-hyperuricemia effects and mechanisms of active compounds in Chinese medicines, single Chinese medicinal herbs, and Chinese medicinal prescriptions in regulating the uric acid level via intestinal flora and metabolites, which will be helpful for further study and application of Chinese medicines in hyperuricemia treatment.

关键词(KeyWords): 高尿酸血症;肠道菌群;代谢产物;中药;综述
hyperuricemia;intestinal flora;metabolites;Chinese medicine;review

Abstract:

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基金项目(Foundation): 湖南省中医药科研计划项目(202023);; 长沙市自然科学基金项目(kq2007063);; 湖南省中医药研究院重点课题(201906);; 湖南创新型省份建设专项普惠性政策与创新环境建设计划项目(2020WK4003)

作者(Author): 文馨月;唐雪阳;何丹;张海潮;张水寒;曾宏亮;
WEN Xin-yue;TANG Xue-yang;HE Dan;ZHANG Hai-chao;ZHANG Shui-han;ZENG Hong-liang;Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine;Center of Science and Technology Innovation, Hunan University of Chinese Medicine;

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