中国中药杂志

2005, (02)

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口服固体速释制剂的研究进展
Research progress on the oral solid rapidly disintegrating dosage form

沈岚,林晓,徐德生,冯怡
SHEN Lan, LIN Xiao, XU De-sheng, FENG Yi(Shanghai University of Traditional Chinese Medicine, Shanghai 201203)

摘要(Abstract):

口服固体速释制剂以其服用方便、生物利用度高、吸收快、不良反应小等特点 ,日益引起人们的关注。速释机理为速崩、速溶、载体材料对药物溶出的促进作用 ;其剂型包括分散片、冻干速溶片、速释片、速液化咀嚼片、固体分散技术制得的滴丸剂和颗粒剂以及膜剂、干凝胶等。口服固体速释制剂为中药难溶性成分的口服吸收、提高生物利用度提供了一个新途径 ;为中药急症治疗开辟了新剂型 ;为新型药剂辅料的研究提供新思路。口服固体速释制剂在中药领域将有良好的发展前景
Oral solid rapidly-disintegrating dosage form has aroused general concern increasingly because of its characteristics about convenient taking, rapid absorption, high bioavailability and not serious adverse drug reaction. This article introduced its mechanism, which was rapid disintegration, fast dissolution or the promoting dissolving action of supplementary material. This dosage form included dispersible tablets, fast dissolving tablets, fast releasing tablets, droppills, granules and tablets by solid dispersible technology, quick-liquefying chewable tablets and dry elixir. It will become a new way for promoting bioavailability in traditional Chinese medicine difficultly-dissolving composition, create up a new dosage form for treating emergency case by traditional Chinese medicine and give a new thinking for studying new supplementary materials. In brief, oral solid rapidly-disintegrating dosage form will have good prospect in the field of traditional Chinese medicine.

关键词(KeyWords): 口服固体速释制剂;概念;特点;速释机理;剂型
oral solid rapidly-disintegrating dosage form; concept; characteristic; mechanism

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作者(Author): 沈岚,林晓,徐德生,冯怡
SHEN Lan, LIN Xiao, XU De-sheng, FENG Yi(Shanghai University of Traditional Chinese Medicine, Shanghai 201203)

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