中国中药杂志

2009, v.34(22) 2891-2894

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荜茇氯仿部位化学成分研究
Chemical constituents from Piper longum

刘文峰;江志勇;陈纪军;张雪梅;马云保;
LIU Wenfeng1,2,JIANG Zhiyong1,CHEN Jijun1,ZHANG Xuemei1,MA Yunbao1(1.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;2.Graduate School of Chinese Acdemy of Sciences,Beijing 100039,China)

摘要(Abstract):

目的:对胡椒科植物荜茇Piperlongum的化学成分进行研究。方法:荜茇用95%乙醇提取,依次用石油醚、氯仿、正丁醇萃取,对氯仿萃取部分采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,1H-NMR,13C-NMR)进行结构鉴定。结果:从氯仿萃取部分分离鉴定了11个化合物,其中6个酰胺类生物碱,3个倍半萜,2个其他类化合物。分别鉴定为:类对香豆酰哌啶(coumaperine,1),N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine(2),胡椒内酰胺A(piperolactam A,3),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E,4E-pentadienyl]-pirrolidine(4),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E-pentenyl]-pirroli-dine(5),1-[1-oxo-9(3,4-methylenedioxyphenyl)-2E,8E-nonadienyl]-pyrrolidine(6),姜黄酮[R-(-)-turmerone,7],octahydro-4-hydroy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol(8),(+)-aphanamol I(9),二去甲氧基姜黄素(bisdeme-thoxycurcumin,10),去甲氧基姜黄素(demethoxycurcumin,11)。结论:化合物1~11均为首次从荜茇中分离得到。
Objective:To study the chemical constituents of Piper longum.Method:The whole plant of air-dried P.longum was extracted with 95% EtOH.The EtOH extract was suspended in H2O and extracted with petroleum ether,CHCl3 and n-BuOH,successively.The compounds were isolated and purified by column chromatography from the CHCl3 fraction,and identified based on spectral analyses(MS,1H-NMR,13C-NMR).Result:Eleven compounds were isolated from P.longum,and were characterized as coumaperine(1),N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine(2),piperolactam A(3),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E,4E-pentadienyl]-pirrolidine(4),1-[1-oxo-5(3,4-methylenedioxyphenyl)-2E-pentenyl]-pirrolidine(5),1-[1-oxo-9(3,4-methylene dioxyphenyl)-2E,8E-nonadienyl]-pyrrolidine(6),(R)-(-)-turmerone(7),octahydro-4-hydroy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol(8),(+)-aphanamol I(9),bisdemethoxycurcumin(10),demethoxycurcumin(11).Conclusion:Compounds 1-11 were obtained from P.longum for the first time.

关键词(KeyWords): 荜茇;酰胺类生物碱;倍半萜;姜黄素
Piper longum;amides;sesquiterpenes;curcumin

Abstract:

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基金项目(Foundation): 云南省自然科学基金项目(312007C090M)

作者(Author): 刘文峰;江志勇;陈纪军;张雪梅;马云保;
LIU Wenfeng1,2,JIANG Zhiyong1,CHEN Jijun1,ZHANG Xuemei1,MA Yunbao1(1.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;2.Graduate School of Chinese Acdemy of Sciences,Beijing 100039,China)

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