中国中药杂志

2012, v.37(01) 52-56

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

不同煎煮方式对芍药甘草复方大鼠血中移行组分的药动学影响
Pharmacokinetics effect of Shaoyao Gancao compound with different decocting methods on characteristic ingredients in rat plasma after oral administration

沈岚;胡蓉婉;林晓;洪燕龙;冯怡;徐德生;阮克锋;
SHEN Lan1,2,HU Rongwan1,2,LIN Xiao1,2,HONG Yanlong1,FENG Yi1,2,XU Desheng3,RUAN Kefeng1(1.Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 2.College of Chinese Material Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 3.Affiliated Shuguang Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

摘要(Abstract):

目的:探讨不同煎煮方式对芍药甘草复方大鼠血中移行组分的药动学影响,从药动学角度阐释芍药甘草复方相使配伍的合理性。方法:在建立芍药甘草体内成分指纹图谱分析方法的基础上,运用药动学方法比较灌胃给药后不同时间的大鼠血浆中各药味特征移行入血成分含量的变化,并对药动学参数进行方差分析。结果:移行入血的6个成分在体内的吸收趋势均为芍药甘草合煎液大于单煎合并液,其中保留时间为5.2,11.0,12.0,14.6 min处的特征峰具有统计学意义。结论:芍药甘草复方相使配伍在体内吸收以合煎较好,从药动学角度证明了芍药甘草复方相使配伍的合理性。
Objective: To observe the pharmacokinetic effect of Shaoyao Gancao compound on rats using different decocting methods,and to pharmacokinetically detect the the compatibility of the component compounds of the Shaoyao Gancao compound from the pharmacokinetic viewpoint.Method: Based on the established HPLC analytical method of plasma effective constituents,rats were orally administered with a single or mixed decoction of Shaoyao and Gancao.Blood at different times after administering these decoctions were collected,and then variance analysis was made for pharmacokinetic parameters.Result: The results of all six rats indicated that the absorption of the mixed decoction of Shaoyao and Gancao was greater than that of the single decoction.While,the absorption of the characteristic peaks at the retention time of 5.2,11.0,12.0,14.6 min had statistical significance.Conclusion: Shaoyao Gancao compound was proved better than that of the single decoction from the pharmacokinetic viewpoint.

关键词(KeyWords): 芍药甘草复方;相使配伍;药动学
Shaoyao Gancao compound;compatibility;pharmacokinetics

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2009ZX09502-009);; 国家自然科学基金青年科学基金项目(30801548);; 上海市教委科研创新项目(12ZZ1241,0YZ57),上海市教委重点学科项目(J50302),上海市教委科研创新项目(10YZ57);; 上海市青年科技启明星计划A类(08QA14060),上海市青年科技启明星计划A类(08QA14060);; 上海市自然科学基金(09ZR1429600);; 上海市科委研发平台专项(09DZ2292000),上海市科委前沿技术研究发展计划项目(09DZ1973000)

作者(Authors): 沈岚;胡蓉婉;林晓;洪燕龙;冯怡;徐德生;阮克锋;
SHEN Lan1,2,HU Rongwan1,2,LIN Xiao1,2,HONG Yanlong1,FENG Yi1,2,XU Desheng3,RUAN Kefeng1(1.Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 2.College of Chinese Material Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 3.Affiliated Shuguang Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享