中国中药杂志

2008, (14) 1653-1657

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开展中药复方研究的系统生物学思路
Ideas of systems biology on study of traditional Chinese medicine

程肖蕊;周文霞;张永祥;
CHENG Xiao-rui ZHOU Wen-xia ZHANG Yong-xiang (Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

摘要(Abstract):

中药复方是通过大量临床实践产生的具有显著疗效的治疗方法,它强调整体观及辨证论治。将系统生物学宏微并举的成果渗透到中药复方的研究中,形成中药复方研究的系统生物学思路,从药材和制剂的获得、药理和药物代谢动力学的研究,到中药复方二次开发研究,以中医药理论为指导,充分利用现代科学技术揭示中药复方治疗疾病的实质,并进行新药创制,对中医药传承、发扬和光大具有重要意义。
Traditional Chinese medicine(TCM)is the scientific therapeutics derived from the traditional Chinese physician's considerable clinical practice during the long history,with the characteristic of significant clinical therapeutic effects.The therapeutic philosophy of TCM is integrative medicine and pattern differentiation.The ideas of systems biology on the study of TCM were formed af- ter the micro-and macro-outcome of systems biology being used into the practice of study on TCM.It is very important for the inherit- ance and development of TCM to disclose the basic mechanism of the clinical therapeutic effects of TCM and find new drugs,from the herbal preparation,pharmacology and pharmacokinetic to drug development using modem science technologies based on the theory of TCM.

关键词(KeyWords): 中药复方;系统生物学
traditional Chinese medicine;systems biology

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(90709012);; 国家自然科学基金面上项目(30600760);; 国家重点基础研究发展规划(973)项目(G199054401,2004CB518907);; 国家高技术研究与发展计划(863)项目(2007AA02Z400)

作者(Authors): 程肖蕊;周文霞;张永祥;
CHENG Xiao-rui ZHOU Wen-xia ZHANG Yong-xiang (Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

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