中国中药杂志

2012, v.37(09) 1245-1248

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藏药甘青乌头化学成分的研究
Chemical constituents of Aconitum tanguticum

罗明;林丽美;李春;王智民;郭五保;
LUO Ming1,2,3,LIN Limei4,LI Chun2,3,WANG Zhimin2,3,GUO Wubao5(1.Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China; 2.Institute of Chinese Materia Medica,China Academy of Chinese Medicine Sciences,Beijing 100700,China; 3.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Beijing 100700,China; 4.Hunan University of Traditional Chinese Medicine,Changsha 410208,China; 5.Experimental Center of Shaanxi Academy of Traditional Chinese Medici

摘要(Abstract):

目的:研究藏药甘青乌头Aconitum tanguticum的化学成分。方法:采用硅胶,SephadexLH-20凝胶,ODS,制备液相等多种色谱技术进行化合物的分离纯化,通过多种波谱分析方法鉴定化合物结构。结果:从甘青乌头大极性部位分离鉴定了7个化合物,分别为山柰酚-3-O-[α-L-鼠李糖基-(1→6)-β-D-半乳糖苷]-7-O-α-L-鼠李糖苷(1),山柰酚-3-O-[α-L-鼠李糖基-(1→6)-β-D-葡萄糖苷]-7-O-α-L-鼠李糖苷(2),山柰酚-7-O-α-L-鼠李糖苷(3),龙胆苦苷(4),吐叶醇-9-O-β-D-葡萄糖苷(5),二氢吐叶醇-9-O-β-D-葡萄糖苷(6),3,4-二羟基-苯乙醇-β-D-葡萄糖苷(7)。结论:所有化合物均为首次从该植物中分离得到。
Objective:To study the chemical constituents isolated from the whole plant of Aconitum tanguticum.Method:Chemical constituents were isolated and purified from the title plant by using a combination of various chromatographic techniques including column chromatography over silica gel,Sephadex LH-20,ODS and preparative HPLC.Their structures were elucidated by spectroscopic techniques including 1H-NMR,13C-NMR,2D-NMR,and ESI-MS.Result: Seven compounds were isolated from this plant and their structures were identified as kaempferol-3-O-[α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside]-7-O-α-L-rhamnopyranoside(1),kaempferol-3-O-[α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside]-7-O-α-L-rhamnopyranoside(2),kaempferol 7-O-α-L-rhamnopyranoside(3),gentiopicroside(4),vomifoliol-9-O-β-D-glucopyranoside(5),dihydrovomifoliol-9-O-β-D-glucopyranoside(6) and 3,4-dihydroxyphenyl alcohol-β-D-glucopyranoside(7).Conclusion: All the compounds were isolated from this plant for the first time.

关键词(KeyWords): 甘青乌头;黄酮;化学成分
Aconitum tanguticum;flavonoids;chemical constituents

Abstract:

Keywords:

基金项目(Foundation): 国家“重大新药创制”科技重大专项(2009ZX09301-005,2009ZX09308-003)

作者(Authors): 罗明;林丽美;李春;王智民;郭五保;
LUO Ming1,2,3,LIN Limei4,LI Chun2,3,WANG Zhimin2,3,GUO Wubao5(1.Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China; 2.Institute of Chinese Materia Medica,China Academy of Chinese Medicine Sciences,Beijing 100700,China; 3.National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Beijing 100700,China; 4.Hunan University of Traditional Chinese Medicine,Changsha 410208,China; 5.Experimental Center of Shaanxi Academy of Traditional Chinese Medici

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