中国中药杂志

2016, v.41(24) 4598-4604

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基于药效学和指标成分优选鼻鼽颗粒醇沉工艺
Optimization of alcohol precipitation technology of Biqiu granules based on index components and pharmacodynamics

张艳军;刘莉莉;吴云;胡军华;常秀娟;萧伟;晁恩祥;
ZHANG Yan-jun;LIU Li-li;WU Yun;HU Jun-hua;CHANG Xiu-juan;XIAO Wei;CHAO En-xiang;Jiangsu Kanion Pharmaceutical Co.,Ltd.;The Key Laboratory for the New Technique Research of TCM Extraction and Purification;China-Japan Friendship Hospital;

摘要(Abstract):

通过考察对血清组胺,Ig E,IL-4,IFN及TNF-α的影响,评价鼻鼽颗粒醇沉工艺的合理性。以咖啡酸和迷迭香酸的含量为综合指标,采用Plackett-Burman设计筛选影响鼻鼽颗粒水提组醇沉工艺的显著性影响因素;在此基础上,通过Box-Behenken设计对显著性因素进一步优化,确定最佳醇沉工艺。确定鼻鼽颗粒水提组的最佳醇沉工艺条件为:浓缩液相对密度1.15(65℃)、醇浓度70%、静止时间12 h。药效学评价结合Plackett-Burman和Box-Behnken设计实验优化确定的醇沉工艺稳定可行,预测性好,为鼻鼽颗粒的产业化生产提供了可靠依据。
To evaluate the rationality of alcohol precipitation technology of Biqiu granule by investigating its effect on serum histamine,Ig E,IL-4,IFN and TNF-α. The contents of cafferic acid and rosmarinic acid were used as the evaluation indexes,and some factors affecting index were firstly evaluated by Plackett-Burman design; then alcohol precipitation technology was further optimized by Box-Behnken design to determine the optimal alcohol precipitation conditions. The best alcohol precipitation conditions were as follows:the relative density of herb liquor was 1. 15( 65 ℃); the concentration of alcohol was 70%,and standing time was 12 hours. Optimal alcohol precipitation technology of Biqiu granules determined by pharmacodynamic screening,Plackett-Burman and Box-Behnken design tests,was stable and feasible with good predictability,providing reliable basis for the industrialization production of Biqiu granules.

关键词(KeyWords): 鼻鼽颗粒;药效学;Plackett-Burman设计;Box-Behnken设计;醇沉工艺
Biuqiu granules;pharmacodynamics;Plackett-Burman design;Box-Behnken design;alcohol precipitation process

Abstract:

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2013ZX09402203)

作者(Author): 张艳军;刘莉莉;吴云;胡军华;常秀娟;萧伟;晁恩祥;
ZHANG Yan-jun;LIU Li-li;WU Yun;HU Jun-hua;CHANG Xiu-juan;XIAO Wei;CHAO En-xiang;Jiangsu Kanion Pharmaceutical Co.,Ltd.;The Key Laboratory for the New Technique Research of TCM Extraction and Purification;China-Japan Friendship Hospital;

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