中国中药杂志

2014, v.39(22) 4464-4469

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基于数据挖掘的国医大师颜正华含首乌藤处方用药规律研究
Analysis on medication rules of state medical master Yan Zhenghua's prescriptions that including Polygoni Multiflori Caulis based on data mining

吴嘉瑞;郭位先;张晓朦;杨冰;张冰;赵梦迪;盛晓光;
WU Jia-rui;GUO Wei-xian;ZHANG Xiao-meng;YANG Bing;ZHANG Bing;ZHAO Meng-di;SHENG Xiao-guang;Beijing University of Chinese Medicine;

摘要(Abstract):

该研究在收集颜正华教授含首乌藤处方的基础上,基于中医传承辅助系统构建数据库,进而应用关联规则apriori算法,分析含首乌藤处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果显示,含首乌藤处方中高频次药物包括炒酸枣仁、牡蛎、龙骨、丹参、赤芍等,高频次药物组合包括"首乌藤-炒酸枣仁"、"牡蛎-首乌藤"、"首乌藤-龙骨"等,置信度为1的关联规则包括"牡蛎→首乌藤"、"茯苓→首乌藤"、"炒酸枣仁→首乌藤"、"白芍→首乌藤"等,治疗不寐的核心药物组合为龙骨、首乌藤、丹参、牡蛎、远志、珍珠母、茯苓、炒酸枣仁,治疗胸痹的核心药物组合为丹参、首乌藤、炒酸枣仁、瓜蒌、薤白、赤芍。
The prescriptions including Polygoni Multiflori Caulis that built by Pro. Yan were collected to build a database based on traditional Chinese medicine( TCM) inheritance assist system. The method of association rules with apriori algorithm was used to achieve frequency of single medicine,frequency of drug combinations,association rules between drugs and core drug combinations. The data-mining results indicated that in the prescriptions that including Polygoni Multiflori Caulis,the highest frequency used drugs were parched Ziziphi Spinosae Semen,Ostreae Concha,Ossis Mastodi Fossilia,Salviae Miltiorrhizae Radix Et Rhizoma,Paeoniae Rubra Radix,and so on. The most frequent drug combinations were ″Polygoni Multiflori Caulis-parched Ziziphi Spinosae Semen″,″Ostreae Concha-Polygoni Multiflori Caulis″,and ″Polygoni Multiflori Caulis-Ossis Mastodi Fossilia″. The drug association rules of confidence coefficient 1 were ″Ostreae Concha→Polygoni Multiflori Caulis″,″Poria→Polygoni Multiflori Caulis″,″parched Ziziphi Spinosae Semen→Polygoni Multiflori Caulis″,and ″Paeoniae Alba Radix→Polygoni Multiflori Caulis″. The core drug combinations in the treatment of insomnia were Ossis Mastodi Fossilia,Polygoni Multiflori Caulis,Salviae Miltiorrhizae Radix et Rhizoma,Ostreae Concha,Polygalae Radix,Margaritifera Concha,Poria,and parched Ziziphi Spinosae Semen. And the core drug combinations in the treatment of obstruction of Qi in chest were Salviae Miltiorrhizae Radix Et Rhizoma,Polygoni Multiflori Caulis,parched Ziziphi Spinosae Semen,Trichosanthis Fructus,Allii Macrostemonis Bulbus,and Paeoniae Rubra Radix.

关键词(KeyWords): 首乌藤;数据挖掘;关联规则
Polygoni Multiflori Caulis;data mining;association rules

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划项目(2007BAI10B01);; 北京市中医药科技发展基金项目(JJ-2010-70);; 北京中医药大学科研创新团队项目(2011-CXTD-14);; 北京中医药大学“重点学科”开放课题(2013-ZDXKKF-19)

作者(Author): 吴嘉瑞;郭位先;张晓朦;杨冰;张冰;赵梦迪;盛晓光;
WU Jia-rui;GUO Wei-xian;ZHANG Xiao-meng;YANG Bing;ZHANG Bing;ZHAO Meng-di;SHENG Xiao-guang;Beijing University of Chinese Medicine;

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