中国中药杂志

2018, v.43(13) 2770-2776

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

基于网络药理学的大黄利胆片的作用机制研究
Anti-inflammatory mechanism of Dahuang Lidan Pian by network pharmacology

霍晓乾;谷宇;张燕玲;
HUO Xiao-qian;GU Yu;ZHANG Yan-ling;Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine;

摘要(Abstract):

大黄利胆片由大黄、手掌参、余甘子组成,功效为清热利湿、解毒退黄,治疗酒精性脂肪肝、胆汁淤积、胆囊炎等病症疗效显著。3味中药分别是中药、蒙药、藏药的常用药,各自药性特点依附于不同的民族药体系,体现了不同的民族药特色,形成了一个独特的民族药的研究载体。该研究通过分子模拟技术预测了3味药的作用靶标,根据靶标蛋白相互信息构建了大黄利胆片的蛋白相互作用网络。采用分子复合物检测算法(MCODE)进行网络功能模块分析,并对模块功能进行注释。研究发现大黄、余甘子生物网络模块具有功能相似性,主要通过对炎症相关通路的协同调节作用发挥保肝护肝作用,而手掌参则通过调节营养物质代谢和机体生理状态,起到补益气血、调和全方的作用。该研究解释了大黄利胆片配伍发挥保肝护肝作用的作用机制,有助于大黄利胆片的进一步开发研究,为民族药的进一步开发利用提供了借鉴。
Dahuang Lidan Pian contains Rheum palmatum,Gymnadenia conopsea and Phyllanthus emblica,which has a significant effect in the treatment of alcoholic fatty liver,cholestasis and cholecystitis. The efficacy of the formula in traditional Chinese medicine was clearing heat and promoting diuresis,removing dampness,detoxifying and relieving jaundice. These three herbs are widely used in the traditional Chinese medicine,Mongolian medicine and Tibetan medicine. Therefore,the formula was a representative subject in the researches for ethno-drugs. In this research,computer aided drug design methods were used to predict the action targets of the formula.Protein interaction network(PIN) was then constructed,and molecular complex detection(MCODE) clustering algorithm was used to obtain the modules of the formula,so as to analyze the potential action mechanism. The results showed that Rh. palmatum and P. emblica may have a synergistic protective effect on liver function by acting on analogous targets and pathways. G. conopsea regulated metabolic balance of nutrients to strengthen physical fitness. The research explained the liver-protecting mechanism of Dahuang Lidan Pian based on the PIN analysis on molecular network,which provides an reference for the further study of Dahuang Lidan Pian.

关键词(KeyWords): 大黄利胆片;保肝利胆;蛋白互作网络;功能模块
Dahuang Lidan Pian;liver protective;protein interaction network;functional modules

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81573831);; 中央高校基本科研业务费专项(2017-JYB-JS-053)

作者(Author): 霍晓乾;谷宇;张燕玲;
HUO Xiao-qian;GU Yu;ZHANG Yan-ling;Research Center of Traditional Chinese Medicine Information Engineering,Beijing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20180408.003

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享