中国中药杂志

2008, (11) 1272-1274

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怀山药化学成分研究
Studies on chemical constituents of Dioscorea opposita

白冰;李明静;王勇;刘绣华;
BAI Bing,LI Ming-jing,WANG Yong,LIU Xiu-hua(Henan University,Key Lab of Natural Drug and Immune Engineering of Henan Province,College of Chemistry and Chemical Engineering,Kaifeng 475001,China)

摘要(Abstract):

目的:研究怀山药Dioscorea opposite的化学成分。方法:采用硅胶柱色谱分离纯化,薄层色谱及波谱进行化合物结构鉴定。结果:从乙醇提取物中分离并鉴定了12个化合物,分别为棕榈酸(1),β-谷甾醇(2),油酸(3),β-谷甾醇醋酸酯(4),5-羟甲基-糠醛(5),壬二酸(6),β-胡萝卜苷(7),环(苯丙氨酸-酪氨酸)(8),环(酪氨酸-酪氨酸)(9),柠檬酸单甲酯(10),柠檬酸双甲酯(11),柠檬酸三甲酯(12)。结论:化合物3~12为首次从山药中分离得到,其中化合物8,9为首次从薯蓣科植物中分离得到的环二肽类型化合物,化合物9为新天然产物。
Objective: To study the chemical constituents of Dioscorea opposita.Method: The chemical constituents were isolated and purified by silica gel column chromatography,and the structures were elucidated by their spectroscopic data and physico-chemical properties.Result: Twelve compounds were obtained and identified as palmitic acid(1),β-sitosterol(2),oleic acid(3),β-sitosterol acetate(4),5-(hydroxymethyl)furfural(5),nonanedioic acid(6),β-daucosterol(7),cyclo-(Phe-Tyr)(8),cyclo-(Tyr-Tyr)(9),6-methyl citrate(10),1,5-dimethyl citrate(11),trimethyl citrate(12).Conclusion: Compounds 3-12 were isolated from this plant for the first time and cyclodipeptides were firstly isolated from the Dioscoreae family;Compound9 was a new natural product.

关键词(KeyWords): 山药;化学成分;环二肽
Dioscorea opposita;chemical constituents;cyclodipeptides

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基金项目(Foundation): 国家科技支撑计划(2006BAI06A20-08);; 河南省高校杰出科研人才基金(2004KYCX018);; 河南省杰出青年科学基金(0612001100)

作者(Author): 白冰;李明静;王勇;刘绣华;
BAI Bing,LI Ming-jing,WANG Yong,LIU Xiu-hua(Henan University,Key Lab of Natural Drug and Immune Engineering of Henan Province,College of Chemistry and Chemical Engineering,Kaifeng 475001,China)

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