中国中药杂志

2014, v.39(24) 4782-4786

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效应面法优化九味熄风颗粒一步制粒工艺
Optimization of one-step pelletization technology of Jiuwei Xifeng granules by response surface methodology

王秀海;杨绪芳;范业文;张艳军;徐忠坤;杨林勇;王振中;萧伟;
WANG Xiu-hai;YANG Xu-fang;FAN Ye-wen;ZHANG Yan-jun;XU Zhong-kun;YANG Lin-yong;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine;

摘要(Abstract):

该研究利用Plackett-Burman设计试验,以颗粒合格率为指标,对影响九味熄风颗粒一步制粒的6个因素进行考察,确定主要影响因素。在此基础上,利用Box-Behnken中心复合原理设计3因素3水平实验,以颗粒合格率、休止角为指标优化实验结果,确定九味熄风颗粒最佳一步制粒工艺条件实际工艺为:进样速度29 r·min-1,进风温度90℃,进风频率34Hz。优化方案制得的颗粒与效应面模型预测值基本一致,优选的生产工艺符合生产要求。
Using the qualified rates of particles as the evaluation indexes,the impact factors of one-step pelletization technology of Jiuwei Xifeng granules were selected from six factors by the Plackett-Burman experimental design and the levels of non-significant factors were identified.According to the Plackett-Burman experimental design,choosing the qualified rates of particles and angle of repose as the evaluation indexes,three levels of the three factors were selected by Box-Behnken of central composite design to optimize the experimental.The best conditions were as follows:the fluid extract was sprayed with frequency of 29 r·min-1,inlet air temperature was 90 ℃,the frequency of fan was 34 Hz.Under the response surface methodology optimized scheme,the average experimental results are similar to the predicted values,and surface methodology could be used in the optimization of one-step pelletization for Chinese materia medica.

关键词(KeyWords): 九味熄风颗粒;效应面法;一步制粒;Plackett-Burman设计;Box-Behnken设计
Jiuwei Xifeng granules;response surface methodology;one-step pelletization;Plackett-Burman design;Box-Behnken design

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作者(Authors): 王秀海;杨绪芳;范业文;张艳军;徐忠坤;杨林勇;王振中;萧伟;
WANG Xiu-hai;YANG Xu-fang;FAN Ye-wen;ZHANG Yan-jun;XU Zhong-kun;YANG Lin-yong;WANG Zhen-zhong;XIAO Wei;Jiangsu Kanion Pharmaceutical Co.,Ltd.;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine;

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