中国中药杂志

2013, v.38(20) 3520-3524

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苦参中非生物碱类成分研究
Non-alkaloid components from Sophora flavescens

张翅;马悦;高慧敏;刘晓谦;陈两绵;张启伟;王智民;李安平;
ZHANG Chi;MA Yue;GAO Hui-min;LIU Xiao-qian;CHEN Liang-mian;ZHANG Qi-wei;WANG Zhi-min;LI An-ping;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines;Tianjin University of Traditional Chinese Medicine;Shanxi Zhendong Pharmaceutical Limited Company;

摘要(Abstract):

该文采用硅胶和HPLC等色谱手段,从苦参茎叶中分离得到5个化合物,从苦参根中分离得到10个化合物;根据化合物的波谱数据,分别鉴定为corchionoside C(1),丁香苷(2),2'-脱氧胸腺嘧啶核苷(3),松柏苷(4),benzyl O-β-D-glucopyranoside(5),番石榴酸(6),三叶豆紫檀苷(7),苦参酮(8),三叶豆紫檀苷-6'-单乙酸酯(9),槐属二氢黄酮G(10),异腐醇(11),降脱水淫羊藿素(12),4'-甲氧基异黄酮-7-O-β-D-芹糖-(1→6)-β-D-吡喃葡萄糖苷(13),kushenol O(14)和6″-木糖-染料木素葡萄糖苷(15),其中化合物1~6为首次从该属植物分离得到。
Five compounds were obtained from the stems and leaves of Sophora flavescens Ait. and ten compounds were obtained from the roots of S. flavescens by various chromatography methods including silica gel column chromatography and preparative HPLC. Their structures were identified on the basis of spectroscopic methods including1H-NMR,13C-NMR and ESI-MS,as corchionoside C( 1),syringing( 2),2'-deoxythymidin( 3),coniferin( 4),benzyl O-β-D-glucopyranoside( 5),piscidic acid( 6),trifolirhizin( 7),kurarinone( 8),trifolirhizin-6'-monoacetate( 9),sophoraflavanone G( 10),isoxanthohumol( 11),noranhydroicaritin( 12), 4'-methoxyisoflavone-7-O-β-D-apiofuranosyl-( 1→6)-β-D-glucopyranoside( 13),kushenol O( 14) and 6″-β-D-xylopyranosylgenistin( 15). Compounds 1-6 were isolated from the Sophora genus for the first time.

关键词(KeyWords): 槐属;苦参;异黄酮
Sophora;Sophora flavescens;isoflavone

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基金项目(Foundation): 国家“十二五”科技支撑计划项目(2011BA107B03);; 国家“重大新药创制”科技重大专项(2008ZX09202-009,2009ZX09308-003)

作者(Author): 张翅;马悦;高慧敏;刘晓谦;陈两绵;张启伟;王智民;李安平;
ZHANG Chi;MA Yue;GAO Hui-min;LIU Xiao-qian;CHEN Liang-mian;ZHANG Qi-wei;WANG Zhi-min;LI An-ping;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines;Tianjin University of Traditional Chinese Medicine;Shanxi Zhendong Pharmaceutical Limited Company;

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