中国中药杂志

2021, v.46(24) 6574-6578

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基于中西医临床病证特点的高血压病动物模型分析
Analysis of animal models of hypertension based on characteristics of clinical symptoms of Chinese and western medicine

黄淑敏;廖晓倩;王梓仪;胡思远;胡志希;
HUANG Shu-min;LIAO Xiao-qian;WANG Zi-yi;HU Si-yuan;HU Zhi-xi;Hunan University of Chinese Medicine;

摘要(Abstract):

高血压病是以血压升高、头晕等为主要临床表现的以人体动脉压升高为主的心血管疾病。该病患病率高,控制率低,影响人们的生活质量,故建立良好的高血压病动物模型对于其诊断及临床防治有着重要意义。该文基于高血压病的中西医临床特点,对目前常见的高血压病动物模型进行归纳总结,主要有基因相关性、手术性、药物诱导性及环境诱导性四大类。在模型评价中,基因相关性高血压病模型中的遗传自发性高血压病大鼠模型;手术性高血压病模型中的两肾一夹法、一肾一夹法、双肾双夹法、腹主动脉缩窄法模型;药物诱导性高血压病模型中的醋酸去氧皮质酮诱导模型;饮食相关性诱导高血压病模型中的高脂高嘌呤饮食模型等方法与临床吻合度较高。该文在分析高血压病动物模型的优缺点及其与中西医临床特征的吻合度的同时提出相应的高血压病动物模型评价和改进方向。为进一步完善中西医临床病证特点的高血压病动物模型体系的建立提供建议,使高血压病动物模型更贴近于临床,对高血压病的临床诊断与治疗起到重要作用。
Hypertension, a cardiovascular disease with main clinical manifestations of dizziness and elevated blood pressure, especially elevated arterial pressure, features high prevalence rate and low control rate, which affects patients′ quality of life. Therefore, establishing a good animal model of hypertension is of great significance for its diagnosis and clinical prevention and treatment. Based on the clinical characteristics of hypertension in traditional Chinese and western medicine, this study summarized the advantages and disadvantages of current hypertension animal models: gene-related model, surgery-caused model, drug-induced model, and environment-induced model, and investigated the similarity to the clinical symptoms in traditional Chinese medicine and Western medicine. Among them, spontaneously hypertensive rats, models established with the surgical two-kidney one-clip, one-kidney one-clip, two-kidney two-clip, and abdominal aorta constriction methods, models induced with the drug deoxycorticosterone acetate, and models induced with the high-fat high-purine diet showed symptoms highly similar to the clinical manifestations. Then, the corresponding evaluation and improvement methods of hypertension animal models were proposed. This study provides suggestions for the establishment of hypertension animal model so that the symptoms are more similar to the clinical characteristics of hypertension in traditional Chinese and Western medicine, which is important for the clinical diagnosis and treatment of hypertension.

关键词(KeyWords): 高血压病;动物模型;临床病证特点
hypertension;animal models;clinical symptoms

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81774208);; 广东省重点领域研发项目(2020B1111100001);; 湖南省自然科学基金项目(2020JJ4062,2019JJ50447,2020JJ5408);; 湖南省研究生科研创新项目(CX20200784);; 湖南省学位与研究生教改重大课题(2020JGZX012);; 湖南省研究生培养创新基地项目(2019-45);; 湖南省中医药科研项目(2021180);; 湖南中医药大学科研基金项目(2019XJJJ012)

作者(Author): 黄淑敏;廖晓倩;王梓仪;胡思远;胡志希;
HUANG Shu-min;LIAO Xiao-qian;WANG Zi-yi;HU Si-yuan;HU Zhi-xi;Hunan University of Chinese Medicine;

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