中国中药杂志

2015, v.40(17) 3480-3487

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三七皂苷类成分及对心血管作用的研究进展
Structure and biological action on cardiovascularsystems of saponins from Panax notoginseng

李娟;王如锋;杨莉;王峥涛;
LI Juan;WANG Ru-feng;YANG Li;WANG Zheng-tao;Department of Pharmacognosy,China Pharmaceutical University;The Ministry of Education Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine;

摘要(Abstract):

三七为五加科植物三七Panax notoginseng的根及根茎,为常用中药,具有止血、散瘀、消肿、止痛等功能。此外,其茎叶、花、果实在民间也做药用。三七的主要药效成分为达玛烷型皂苷,具有较强的生物活性,引起医药界的广泛关注。现已从三七及其地上部分分离得到近百种皂苷类成分。根据苷元结构的不同,分为4类,分别为PPD型,PPT型,C17侧链变化型以及其他类型。该研究对三七的不同部位中的皂苷类化学成分进行了系统归纳,同时对三七皂苷在心血管方面的药理活性进行综述。
Notoginseng Radix et Rhizoma( Sanqi),the underground part of Panax notoginseng( Burk.) F. H. Chen( Araliaceae)is commonly used in Chinese medicine for treatment of haemorrhage,haemostasis,swelling,etc. The aerial part including leaves,flowers and fruits are also applied for similar functions. Triterpenoid saponins are considered to be responsible for the biological activities of Sanqi. Up to date,more than 100 saponins have been isolated from theroots,rhizomes,leaves,flowers and fruits of P. notoginseng.The reported saponins can be classified into protopanaxadiol( PPD),protopanaxatriol( PPT),C17 side-chain varied and other types,according to the skeletons of the aglycons. The present review summarizes the saponins isolated from P. notoginseng and their distribution in different medicinal organs,as well as the pharmacological actions on cardiovascular system.

关键词(KeyWords): 三七;皂苷类;分布;心血管药理活性
Panax notoginseng;saponins;distribution;cardiovascular system

Abstract:

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基金项目(Foundation): 国家自然科学基金项目(U1032604);; 上海市科学技术委员会科研计划项目(12401900403)

作者(Author): 李娟;王如锋;杨莉;王峥涛;
LI Juan;WANG Ru-feng;YANG Li;WANG Zheng-tao;Department of Pharmacognosy,China Pharmaceutical University;The Ministry of Education Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine;

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