中国中药杂志

2015, v.40(04) 588-593

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丹参及其主要成分保肝作用的研究进展
Advance in studies on hepatoprotective effect of Salvia miltiorrhiza and its main components

袁媛;吴芹;石京山;陈修平;
YUAN Yuan;WU Qin;SHI Jing-shan;CHEN Xiu-ping;Department of Pharmacology,Zunyi Medical College,Key Laboratory of Basic Pharmacology of Guizhou Province;State Key Laboratory of Quality Research for Traditional Chinese Medicines,Institute of Chinese Medical Sciences,University of Macau;

摘要(Abstract):

丹参是临床最常用的中药之一,丹参的药效物质基础主要包括脂溶性的丹参酮类和水溶性的丹酚酸类。丹参具有"祛瘀止痛,活血通经,清心除烦"等传统功效。现代药理学研究表明,丹参及其主要成分具有保护心脑血管的作用。近来研究显示,丹参及其主要成分对四氯化碳、D-氨基半乳糖、醋氨酚、酒精等制备的肝损伤模型也具有明显的保护作用。该文对丹参的保肝作用及其机制进行系统总结与展望。
Dried roots and rhizomes of Salvia miltiorrhiza( Danshen) are among the most commonly used traditional Chinese medicines in clinic. The material basis for its efficacy mainly includes hydrophobic tanshinones and hydrophilic salvianolic acids. The traditional effects of Danshen are ″removing stasis and relieving pain,activating blood to promote menstruation,clearing heart fire and tranquilization″. According to modern pharmacological studies,Danshen and its main components have cardiovascular and cerebrovascular protective effect. Recent studies showed that Danshen and its main components also demonstrated protective effects on liver injury models induced by carbon tetrachloride,D-galactosamine,acetaminophen and alcohol. In this paper,the hepatoprotective effect and mechanism of Danshen were summarized and studied.

关键词(KeyWords): 丹参;肝脏保护作用;丹参提取物;丹参酮ⅡA;隐丹参酮;丹参素;丹酚酸A;丹酚酸B
Salvia miltiorrhiza;hepatoprotective effect;extracts from S.miltiorrhiza;tanshinone ⅡA;cryptotanshinone;salvianolic acid A;salvianolic acid B

Abstract:

Keywords:

基金项目(Foundation): 澳门科学技术发展基金项目(021/2012/A1);; 澳门大学研究基金项目(MRG007/CXP/2013/ICMS)

作者(Author): 袁媛;吴芹;石京山;陈修平;
YUAN Yuan;WU Qin;SHI Jing-shan;CHEN Xiu-ping;Department of Pharmacology,Zunyi Medical College,Key Laboratory of Basic Pharmacology of Guizhou Province;State Key Laboratory of Quality Research for Traditional Chinese Medicines,Institute of Chinese Medical Sciences,University of Macau;

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