中国中药杂志

2019, v.44(14) 3064-3069

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龙牙花根中化学成分的研究
Chemical compositions from roots of Erythrina corallodendron

丁雯倩;史国茹;庾石山;
DING Wen-qian;SHI Guo-ru;YU Shi-shan;Hunan University of Chinese Medicine;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;

摘要(Abstract):

研究蝶形花科刺桐属植物龙牙花Erythrina corallodendron中的化学成分和生物活性。利用硅胶柱色谱、反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱以及制备型HPLC等色谱技术从龙牙花根95%乙醇提取物中分离得到15个化合物,通过波谱学技术鉴定它们的结构分别为10,11-dioxoerythraline(1),erythrinine(2),erythraline(3),11-methoxyerythraline(4),cristanines B(5),erythratine(6),erysotrine(7),杜仲树脂酚(8),(±)-ficusesquilignan A(9),松脂素(10),烟酸(11),邻苯二甲酸丁二脂(12),香草酸(13),3-羟基-1-(4-羟基-3-甲氧基苯)-1-丙酮(14),丁香酸(15)。化合物8~10首次从该属中分得,所有化合物均首次从该种中分得。采用肝微粒体氧化抑制模型和MTT法对从中分离得到的生物碱单体化合物进行了抗氧化活性和细胞毒活性的筛选。
This project is to investigate chemical compositions from the roots of Erythrina corallodendron. Through the methods of silica gel,ODS,Sephadex LH-20 column chromatography and preparative HPLC,15 compounds were isolated from the 95% ethanol extract of the roots of E. corallodendron. Based on spectroscopic techniques,the structures of these compounds were identified as 10,11-dioxoerythraline( 1),erythrinine( 2),erythraline( 3),11-methoxyerythraline( 4),cristanines B( 5),erythratine( 6),erysotrine( 7),medioresinol( 8),( ±)-ficusesquilignan A( 9),( +)-pinoresinol( 10),nicotinic acid( 11),dibutyl phthalate( 12),vanillic acid( 13),3-hydroxy-1-( 4-hydroxy-3-methoxyphenyl)-1-propanone( 14),and syringic acid( 15). Compounds 8-10 are isolated from genus Erythrina for the first time and all compounds are isolated from E. corallodendron for the first time. Furthermore,this paper screened the antioxidant and cytotoxic activities of the compounds using models of liver microsomal oxidation inhibition and MTT.

关键词(KeyWords): 刺桐属;龙牙花;化学成分;刺桐生物碱;药理活性
Erythrina;Erythrina corallodendron;chemical composition;erythrina alkaloid;pharmacological activity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(21732008)

作者(Authors): 丁雯倩;史国茹;庾石山;
DING Wen-qian;SHI Guo-ru;YU Shi-shan;Hunan University of Chinese Medicine;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;

DOI: 10.19540/j.cnki.cjcmm.20190520.204

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