中国中药杂志

2011, v.36(11) 1516-1518

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丹参素钠与丹参注射液中丹参素在小鼠体内的组织分布
Tissue distribution in mice of danshensu from sodium danshensu and Salvia miltiorrhiza injection

王娟;马张庆;洪宗元;宋建国;
WANG Juan,MA Zhangqing,HONG Zongyuan,SONG Jianguo(Department of Pharmacology,Wannan Medical College,Institute of Quantitative Pharmacology,Grade Ⅲ Laboratory,Pharmacology of Traditional Chinese Medical,State of Administration of Traditional ChineseMedicine of China,Wuhu 241002,China)

摘要(Abstract):

目的:以丹参素为指标,检测丹参素钠与丹参注射液的组织分布,初步探讨丹参注射液中其他成分对丹参素体内分布的影响。方法:小鼠随机分为2组,分别腹腔注射丹参素钠和丹参注射液(含丹参素60 mg.kg-1),给药后30 m in处死,HPLC测心、肝、脾、肺、肾等组织丹参素浓度,比较2组差异。结果:丹参素浓度从大到小,丹参素钠组依次为C肾>C脾>C肺>C心>C肝,丹参注射液组依次为C肾>C肺>C脾>C心≈C肝。心、肝、脾、肾等组织丹参素浓度2组间均有差异。结论:丹参注射液中其他成分可影响丹参素的体内分布。
Objective:To determine the concentration in mice of danshensu from sodium danshensu and Salvia miltiorrhiza injection and undertake comparative study of them as well as to assess the effect of other components of S.miltiorrhiza injection on the tissue distribution of danshensu.Method:Mice received intraperitoneal administration of sodium danshensu or S.miltiorrhiza injection(equal to danshensu 60 mg·kg-1) respectively,and was executed 30 minutes after administration.The concentration of danshensu in different tissues was separately determined by high performance liquid chromatographic method.Result:The characteristic profiles of sodium danshensu in different tissues were Ckidney>Cspleen> Clung> Cheart >Cliver.The characteristic profiles of danshensu from S.miltiorrhiza injection in different tissues were Ckidney>Clung>Cspleen>Cheart≈Cliver.The concentration of danshensu in S.miltiorrhiza injection in liver and kindey was higher than sodium danshensu itself.Conclusion:It was suggested that the other components in S.miltiorrhiza injection influent the distribution profile in tissues of danshensu.

关键词(KeyWords): 丹参素;丹参注射液;组织分布;液相色谱
danshensu;Salvia miltiorrhiza injection;tissue distribution;HPLC

Abstract:

Keywords:

基金项目(Foundation): 安徽省高校省级自然科学研究项目(KJ2008B084);; 教育部科学技术重点项目(208058)

作者(Author): 王娟;马张庆;洪宗元;宋建国;
WANG Juan,MA Zhangqing,HONG Zongyuan,SONG Jianguo(Department of Pharmacology,Wannan Medical College,Institute of Quantitative Pharmacology,Grade Ⅲ Laboratory,Pharmacology of Traditional Chinese Medical,State of Administration of Traditional ChineseMedicine of China,Wuhu 241002,China)

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