中国中药杂志

2019, v.44(02) 224-228

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基于药性组合的丹参和红花的性效关系研究
Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination

候宁;吴东雪;刘敏;李晶;张燕玲;乔延江;
HOU Ning;WU Dong-xue;LIU Min;LI Jing;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

摘要(Abstract):

丹参和红花为活血化瘀药的常用药,但因其四气、五味的不同,二者功效大不相同。该研究选取丹参、红花为研究载体,通过TCMD,TCMSP数据库和Ch EMBL数据库,获取2味中药的有效成分及成分作用靶点,应用STRING在线数据库获取各靶点相关的蛋白互作信息导入Cytoscape平台,绘制蛋白互作网络并进行GO富集分析。结果表明,寒-苦药性组合蛋白互作网络特异性参与血管收缩生物过程,通过调节血管收缩从而发挥凉血消痈的功效;温-辛蛋白互作网络特异性参与血液凝固、脂质代谢、免疫调节过程,通过调节血液黏稠度、血脂异常、免疫炎症因子的分泌从而发挥祛瘀止痛的功效;心-肝经蛋白互作网络通过参与血液循环、磷脂酶代谢、肝脏脂质代谢等生物过程从而靶向作用于心脏、肝脏,发挥活血调经的功效。通过分析发现药理药效与药性研究具有一定特异性的联系,便于后续在该研究基础上进行药性的科学性与系统性研究。
Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are commonly traditional Chinese medicines with invigorating blood circulation and eliminating blood stasis,but they are different in effects due to differences in five tastes and four properties. In this study,Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are selected as research vectors to obtain the active ingredients and targets through TCMD,TCMSP database and Ch EMBL database. The protein interaction information of the target is used to obtain from STRING online database,then imported into Cytoscape software to plot the protein interaction network and perform GO enrichment analysis.The results show that the heart-liver protein interaction network,involving blood circulation and hepatic lipid metabolism,thereby exerting the effect of activating blood circulation. The cold-bitter protein interaction network involves the biological process of vasoconstriction,thereby exerting cooling blood and the efficacy of eliminating phlegm. The warm-pungent protein interaction network involves blood coagulation,lipid metabolism and other biological processes to play the role of phlegm pain. Through analysis,it is found that the relationship between pharmacological efficacy and medicinal properties has a certain degree of specificity,which facilitates the subsequent scientific and systematic study of medicinal properties on the basis of this study.

关键词(KeyWords): 丹参;红花;活血化瘀;药性组合;寒苦;温辛
Salviae Miltiorrhizae Radix et Rhizoma;Carthami Flos;promoting blood circulation and removing blood stasis;nature combination;cold-bitter;warm-pungent

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金重点项目(81430094)

作者(Author): 候宁;吴东雪;刘敏;李晶;张燕玲;乔延江;
HOU Ning;WU Dong-xue;LIU Min;LI Jing;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20180903.002

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