中国中药杂志

2012, v.37(02) 255-257

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异亚丙基莽草酸血浆蛋白结合率的测定
Determination of plasma protein binding rate of isopropylidene-shikimic acid

孔慧;邢红霞;刘瑾;闫磊;林龙飞;倪健;
KONG Hui1,XING Hongxia2,LIU Jin3,YAN Lei1,LIN Longfei1,NI Jian1(1.Beijing University of Chinese Medicine,Beijing 100102,China; 2.Qufu Hospital of Chinese Medicine,Qufu 273100,China; 3.Shandong Provincial Institute of Traditional Chinese Medicine and Chinese Matera Madica,Jinan 250014,China)

摘要(Abstract):

目的:测定异亚丙基莽草酸的血浆蛋白结合率。方法:采用超滤法结合高效液相色谱法对异亚丙基莽草酸与犬血浆及人血浆的蛋白结合率进行测定。结果:异亚丙基莽草酸与犬血浆在0.3,0.15 g.L-1,0.5 mg.L-1下的血浆蛋白结合率分别为(4.36±0.02)%,(4.12±0.19)%,(2.23±0.59)%。异亚丙基莽草酸在以上3个浓度下与健康人血浆蛋白结合率分别为(11.23±0.01)%,(10.06±0.69)%,(9.72±0.59)%。结论:异亚丙基莽草酸与血浆蛋白的结合较弱。
Objective:To study the plasma protein binding rate of isopropylidene-shikimic acid.Method:The ultrafiltration was employed to determine the plasma protein binding rate of isopropylidene-shikimic acid.The plasma concentrations of isopropylidene-shikimic acid were measured by HPLC.Result:The plasma protein binding rate of isopropylidene-shikimic acid with dog plasma at the concentration of 0.3,0.15 g·L-1 and 0.5 mg·L-1 were(4.36±0.02)%,(4.12±0.19)% and(2.23±0.59)%,respectively.While the plasma protein binding rate of isopropylidene-shikimic acid with normal human plasma at the above concentrations were(11.23±0.01)%,(10.06±0.69)% and(9.72±0.59)%,respectively.Conclusion:The binding rate of isopropylidene-shikimic acid with plasma protein is low.

关键词(KeyWords): 异亚丙基莽草酸;血浆蛋白结合率;超滤法;高效液相色谱法
isopropylidene-shikimic acid;plasma protein binding rate;ultrafiltration;HPLC

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作者(Author): 孔慧;邢红霞;刘瑾;闫磊;林龙飞;倪健;
KONG Hui1,XING Hongxia2,LIU Jin3,YAN Lei1,LIN Longfei1,NI Jian1(1.Beijing University of Chinese Medicine,Beijing 100102,China; 2.Qufu Hospital of Chinese Medicine,Qufu 273100,China; 3.Shandong Provincial Institute of Traditional Chinese Medicine and Chinese Matera Madica,Jinan 250014,China)

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