中国中药杂志

2001, (07)

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

黄芪总黄酮对扑热息痛所致小鼠肝损伤防护作用的研究
Studies on Protective Effect of Total Flavonoids of Astragalus on Liver Damage Paracetamol-Inducedby

汪德清,丁保国,马艳青,赵海潞,Thomas G Neil,Tomlinson Brian,田亚平,王成彬,Critchley Julian AJH
WANG De-qing 1,2 , DING Bao-guo 1, MA Yan-qing 1, ZHAO Hai-lu 1, Thomas G Neil 1, Tomlinson Brian 1, TIAN Ya-ping 2, WANG Cheng-bin 2, Critchley Julian AJH 1 (1.Division of Clinical Pharmacology, Department of Medicine and Therapeutics; T

摘要(Abstract):

目的 :研究黄芪总黄酮 (TFA)对扑热息痛所致肝损伤的防护作用。方法 :用 1%羧甲基纤维素钠 10ml·kg-1,TFA10 0mg·kg-1或维生素C (Ascorbicacid ,VC) 10 0 0mg·kg-1给小鼠灌胃 1h后 ,灌扑热息痛 10 0 0mg·kg-1,观察小鼠死亡率的变化 ;提前 1h用不同剂量的TFA或VC处理后 ,再灌 40 0mg·kg-1的扑热息痛 ,检测血清酶学和肝脏组织学的改变。结果 :给小鼠扑热息痛 10 0 0mg·kg-1灌胃组 ,2 4h后可致 80 %小鼠死亡 ;提前 1h用TFA10 0mg·kg-1或VC灌胃其死亡率可分别下降至 2 0 %和 0 %。血清转氨酶 (ALT)和病理切片显示当给 40 0mg·kg-1扑热息痛灌胃 2 4h后即可引起严重肝损伤 (ALT升高和肝组织大面积坏死 ,P <0 .0 0 1)。TFA或VC预防组 (提前 1h给药 )的肝损伤程度与对照组比较明显减轻 ,其作用强度与药物浓度成正比。结论 :TFA对扑热息痛所致肝损伤有保护作用。
Objective: To study the protective effect of total flavonoids of Astragalus (TFA) on the liver against large doses of paracetamol in mice. Method:After oral administration of TFA or Vitamin C 1 h prior to giving large dose of paracetamol in mice, the changes of paracetamol-induced mortality rate, serum enzyme level and liver damage degree were obsezved. Result: Paracetamol produced 80% mortality, within 24 hours of the administration of a dose of 1 000 mg·kg -1 to the mice. Pre-treatment of the animals with TFA (100 mg·kg -1 ) or Vitamin C (1 000 mg·kg -1 ) reduced the death rate to 20% and0% respectively. There was also a significant rise in the serum enzyme level of alanine transaminase (P<0.001) and the area of liver necrosis (P<0.001), 24 h after paracetamol (400 mg·kg -1 ) treatment. With pre-treatment with either TFA or Vitamin C, there was an obvious dose-dependent decrease in ALT levels and the area of hepatocellular necrosis. Conclusion: TFA has potential protecting effect against the paracetamol-induced hepatic damage. [

关键词(KeyWords): 黄芪总黄酮;扑热息痛;肝损伤;维生素C
total flavonoids of Astragalus, paracetamol, liver damage, Vitamin C

Abstract:

Keywords:

基金项目(Foundation): 香港特区科学基金 (RGC ;;4134/ 0 0M )

作者(Author): 汪德清,丁保国,马艳青,赵海潞,Thomas G Neil,Tomlinson Brian,田亚平,王成彬,Critchley Julian AJH
WANG De-qing 1,2 , DING Bao-guo 1, MA Yan-qing 1, ZHAO Hai-lu 1, Thomas G Neil 1, Tomlinson Brian 1, TIAN Ya-ping 2, WANG Cheng-bin 2, Critchley Julian AJH 1 (1.Division of Clinical Pharmacology, Department of Medicine and Therapeutics; T

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享