中国中药杂志

2021, v.46(19) 4875-4880

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中药自组装纳米粒的形成及应用研究进展
Advances in formation and application of self-assembled nanoparticles from traditional Chinese medicine

沈成英;胡菲;朱君君;李小芳;申宝德;袁海龙;
SHEN Cheng-ying;HU Fei;ZHU Jun-jun;LI Xiao-fang;SHEN Bao-de;YUAN Hai-long;Department of Pharmacy,Air Force Medical Center;School of Pharmacy,Chengdu University of Traditional Chinese Medicine;

摘要(Abstract):

中药化学成分由于来源多样,结构独特,易自组装形成纳米粒。中药自组装纳米粒(self-assembled nanoparticles, SAN)的形成不仅可以影响中药有效成分的吸收分布,还可能具有优于有效成分或其简单混合物的生物活性;这对于揭示中药配伍机制,中药新药发现及开发新型纳米材料等具有重要意义。该文在概述中药SAN的基础上,重点对中药SAN的形成、分离与表征及应用进行综述,并对中药SAN研究中存在的问题及发展趋势进行分析探讨,以期为中药SAN的深入研究提供借鉴和思考,推动中药SAN现代研究与应用的创新与发展。
Due to the diverse sources and unique structures, the chemical components of Chinese medicinal materials are easy to self-assemble to form nanoparticles. The formation of self-assembled nanoparticles(SAN) can not only affect the absorption and distribution of the effective ingredients in Chinese medicinal materials but also may improve the biological activity of the effective ingredients or their simple mixtures, which is of great significance for revealing the compatibility mechanism of Chinese medicine prescription, developing new Chinese medicine products, and producing new nanomaterials. This paper reviews the formation, isolation, characterization, and application of SAN of Chinese medicines, and discusses the problems and development trends of the relevant research, which can provide reference for the further study and promote the innovation and application of such SAN.

关键词(KeyWords): 中药;自组装纳米粒;形成;分离与表征;应用;研究进展
Chinese medicines;self-assembled nanoparticles;formation;isolation and characterization;application;research progress

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基金项目(Foundation): 国家自然科学基金青年基金项目(81803741);国家自然科学基金面上项目(81873092)

作者(Author): 沈成英;胡菲;朱君君;李小芳;申宝德;袁海龙;
SHEN Cheng-ying;HU Fei;ZHU Jun-jun;LI Xiao-fang;SHEN Bao-de;YUAN Hai-long;Department of Pharmacy,Air Force Medical Center;School of Pharmacy,Chengdu University of Traditional Chinese Medicine;

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