中国中药杂志

2021, v.46(19) 4898-4906

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胆汁类动物药中胆汁酸化学成分和药理作用研究进展
Chemical constituents and pharmacological action of bile acids from animal:a review

陈星玲;宿树兰;刘睿;钱大玮;陈丽玲;邱丽萍;段金廒;
CHEN Xing-ling;SU Shu-lan;LIU Rui;QIAN Da-wei;CHEN Li-ling;QIU Li-ping;DUAN Jin-ao;National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine;The FJ (Fujian) into Allah Pharmaceutical Co.;

摘要(Abstract):

动物胆汁作为药物应用防治疾病有着悠久的历史,主要包括鸡、猪、蛇、牛、熊等的胆汁,而胆汁酸类成分是胆汁的重要活性成分。研究表明,胆汁酸类成分主要包括胆酸、去氧胆酸、鹅去氧胆酸、熊去氧胆酸、牛磺鹅去氧胆酸等,能通过肝肠循环与肠道微生物互相影响,在营养吸收和分配、代谢调节和动态平衡方面起着重要的作用。胆汁中胆汁酸类成分具有保肝、利胆、溶胆结石、抗癌、保护肾脏、保护心脑组织、保护神经、镇咳、平喘、祛痰、治疗眼病、调节肠道功能、调节血糖等药理作用,在临床上应用广泛。为了更好地发挥胆汁酸的药用价值以及在产品开发中的应用,该文通过对药用动物胆汁中胆汁酸类化学成分和药理作用研究进展进行归纳、总结与分析,以期为胆汁酸的进一步开发利用提供科学依据和参考。
Bile of animal(mainly chicken, pig, snake, cow, and bear) has long been used as medicine. As the major active components of bile, bile acids mainly include cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, and taurochenodeoxycholic acid. They interact with intestinal microorganisms in enterohepatic circulation, thereby playing an important part in nutrient absorption and allocation, metabolism regulation, and dynamic balance. Bile acids have pharmacological effects such as protecting liver, kidney, heart, brain, and nerves, promoting bile secretion, dissolving gallstones, anti-cancer, relieving cough and dyspnea, dispelling phlegm, treating eye diseases, and regulating intestinal function and blood glucose, which are widely used in clinical practice. This study summarized and analyzed the research on the chemical constituents and pharmacological effects of bile acids from medicinal animals, in a bid to provide scientific basis and reference for the further development and utilization of bile acids.

关键词(KeyWords): 动物胆汁;胆汁酸;化学成分;肝肠代谢;药理作用
animal bile;bile acid;chemical constituent;hepatointestinal metabolism;pharmacological effect

Abstract:

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基金项目(Foundation): 国家自然科学基金面上项目(81973450)

作者(Author): 陈星玲;宿树兰;刘睿;钱大玮;陈丽玲;邱丽萍;段金廒;
CHEN Xing-ling;SU Shu-lan;LIU Rui;QIAN Da-wei;CHEN Li-ling;QIU Li-ping;DUAN Jin-ao;National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine;The FJ (Fujian) into Allah Pharmaceutical Co.;

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